Genetic characterization of South American infectious bursal disease virus reveals the existence of a distinct worldwide-spread genetic lineage

Avian Pathology : Journal of the W.V.P.A
Martín HernándezRuben Pérez

Abstract

Infectious bursal disease virus (IBDV) is one of the most concerning health problems for world poultry production. IBDVs comprise four well-defined evolutionary lineages known as classic (c), classic attenuated (ca), variant (va) and very virulent (vv) strains. Here, we characterized IBDVs from South America by the genetic analysis of both segments of the viral genome. Viruses belonging to c, ca and vv strains were unambiguously classified by the presence of molecular markers and phylogenetic analysis of the hypervariable region of the vp2 gene. Notably, the majority of the characterized viruses (9 out of 15) could not be accurately assigned to any of the previously described strains and were then denoted as distinct (d) IBDVs. These dIBDVs constitute an independent evolutionary lineage that also comprises field IBDVs from America, Europe and Asia. The hypervariable VP2 sequence of dIBDVs has a unique and conserved molecular signature (272T, 289P, 290I and 296F) that is a diagnostic character for classification. A discriminant analysis of principal components (DAPC) also identified the dIBDVs as a cluster of genetically related viruses separated from the typical strains. DAPC and genetic distance estimation indicated that the d...Continue Reading

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Citations

Oct 3, 2015·Genome Announcements·Gonzalo TomásRuben Pérez
Aug 9, 2018·Avian Pathology : Journal of the W.V.P.A·Daral J JackwoodSjaak de Wit
Dec 14, 2019·Transboundary and Emerging Diseases·Gonzalo TomásRuben Pérez
Aug 22, 2017·Archives of Virology·Linda O Michel, Daral J Jackwood
Jan 5, 2021·Avian Pathology : Journal of the W.V.P.A·Tuyet Ngan ThaiHye-Ryoung Kim
Jan 8, 2021·Avian Pathology : Journal of the W.V.P.A·Mohammad Rafiqul IslamHermann Müller
Jul 23, 2021·Tropical Animal Health and Production·Chandankar Vaidehi DeoraoG Chaithra
Apr 26, 2019·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Aline Padilha de FragaVagner Ricardo Lunge

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Datasets Mentioned

BETA
UY-221201
KP274850-3
AF240686
KM659881-95

Methods Mentioned

BETA
PCR

Software Mentioned

PhyML
DAPC
TreeGraph2
R R Development Core Team
MEGA5
BLAST
jModelTest

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