Genetic characterization of the UCS and Kex1 loci of Pneumocystis jirovecii.

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
Francisco EstevesOlga Matos

Abstract

Nucleotide variation in the Pneumocystis jirovecii upstream conserved sequence (UCS) and kexin-like serine protease (Kex1) loci was studied in pulmonary specimens from Portuguese HIV-positive patients. DNA was extracted and used for specific molecular sequence analysis. The number of UCS tandem repeats detected in 13 successfully sequenced isolates ranged from three (9 isolates, 69%) to four (4 isolates, 31%). A novel tandem repeat pattern and two novel polymorphisms were detected in the UCS region. For the Kex1 gene, the wild-type (24 isolates, 86%) was the most frequent sequence detected among the 28 sequenced isolates. Nevertheless, a nonsynonymous (1 isolate, 3%) and three synonymous (3 isolates, 11%) polymorphisms were detected and are described here for the first time.

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Citations

Aug 21, 2010·Future Microbiology·Olga Matos, Francisco Esteves
Jul 16, 2013·Pathologie-biologie·M A JarbouiA Ayadi
Jan 12, 2010·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Francisco EstevesOlga Matos
Aug 25, 2012·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Rashmi GuptaVishnubhatla Sreenivas
Feb 6, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Lan SunJunchao Gu
Apr 11, 2012·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·F EstevesO Matos
Jun 15, 2018·Clinical Microbiology Reviews·Liang MaJoseph A Kovacs
Jun 20, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Ana Luísa TomásOlga Matos
Nov 5, 2020·Journal of Fungi·Lana PasicWieland Meyer

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