Genetic characterization of thymoma

Scientific Reports
Lei YuDi Gao

Abstract

Thymoma represents the most common anterior mediastinal compartment neoplasm, originating from the epithelial cell population in the thymus. Various histological types of thymoma feature different clinical characteristics. Furthermore, thymoma is frequently associated with autoimmune disorders, esp. myasthenia gravis (MG). However, the underlying molecular tumourigenesis of thymoma remains largely unknown. The goal of our current study is to demonstrate the underlying genetic abberations in thymoma, so as to understand the possible cause of MG in thymoma patients. By using CapitalBio mRNA microarray analysis, we analyzed 31 cases of thymoma including 5 cases of type AB thymoma, 6 B1-type cases, 12 B2-type cases, 5 B2B3-type cases and 3 type-B3 cases. 6 cases of thymoma were not associated with myasthenia gravis, while 25 cases were with myasthenia gravis. By comparisons between thymoma and the paratumoral tissues, differentially expressed genes were identified preliminarily. Among them, 292 genes increased more than 2-fold, 2 genes more than 5-fold. On the other hand, 596 genes were decreased more than 2-fold, 6 genes more than 20-fold. Interestingly, among these genes upregulated more than 2-fold, 6 driver genes (FANCI, NCAPD3...Continue Reading

References

Mar 2, 2002·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Nino MancaCorrado Angelini
Mar 19, 2003·International Journal of Experimental Pathology·Kazunori KikuchiTakashi Yoshiki
Jun 1, 2005·Laboratory Investigation; a Journal of Technical Methods and Pathology·Takahiro TsujiTakashi Yoshiki
Oct 29, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nicolas GirardWilliam Pao
Jan 28, 2010·The Annals of Thoracic Surgery·Stefano MargaritoraPierluigi Granone
Dec 31, 2010·Clinical and Experimental Medicine·Anca Maria CimpeanDomenico Ribatti
Feb 15, 2011·Cellular & Molecular Immunology·Shahar ShellyYehuda Shoenfeld
Apr 29, 2011·The Annals of Thoracic Surgery·Jun ChenQinghua Zhou
Sep 1, 2011·Annals of Surgical Oncology·Lei YuMark J Krasna
Jan 3, 2012·Veterinary Immunology and Immunopathology·Shingo MaedaHajime Tsujimoto
Nov 23, 2012·European Journal of Immunology·Bernard CollinsJohn W Kappler
Jan 7, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Mohamed MokhtarAkira Tangoku
Jul 8, 2014·Oncogenesis·R BelaniA Torkamani
Jan 23, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Anish ThomasGiuseppe Giaccone
Oct 30, 2016·OncoTargets and Therapy·Zhengbo SongYiping Zhang
Jan 14, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Einas M YousefLouis A Gaboury
Mar 18, 2017·Human Pathology·Danielle FortunaJuan Palazzo
Mar 25, 2017·Scientific Reports·Xiaojun ShiAdam W Smith
Apr 30, 2017·Rinshō shinkeigaku = Clinical neurology·Shunsuke TakaiShinya Okada

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Methods Mentioned

BETA
PCR
chromosomal aberrations
electrophoresis

Software Mentioned

CLUSTER
GeneSpring
CapitalBio
GraphPad Prism

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