Genetic clonality of Plasmodium falciparum affects the outcome of infection in Anopheles gambiae

International Journal for Parasitology
Sandrine E NsangoIsabelle Morlais

Abstract

Mosquito infections with natural isolates of Plasmodium falciparum are notoriously variable and pose a problem for reliable evaluation of efficiency of transmission-blocking agents for malaria control interventions. Here, we show that monoclonal P. falciparum isolates produce higher parasite loads than mixed ones. Induction of the mosquito immune responses by wounding efficiently decreases Plasmodium numbers in monoclonal infections but fails to do so in infections with two or more parasite genotypes. Our results point to the parasites genetic complexity as a potentially crucial component of mosquito-parasite interactions.

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Citations

Aug 27, 2013·PloS One·Andrea L SmidlerEric Marois
Jan 1, 2013·Trends in Parasitology·Teun BousemaRhoel R Dinglasan
May 20, 2015·Trends in Parasitology·Will StoneChris Drakeley
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May 8, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Majoline T TchioffoIsabelle Morlais
Aug 10, 2016·Parasites & Vectors·Marie JaloveckaLaurence Malandrin
Oct 23, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Maurice M SandeuIsabelle Morlais
Sep 19, 2016·Trends in Parasitology·Ryan C Smith, Carolina Barillas-Mury
Sep 4, 2014·Memórias do Instituto Oswaldo Cruz·Alvaro Molina-Cruz, Carolina Barillas-Mury
Apr 18, 2013·The Journal of Biological Chemistry·Sandrine E NsangoElena A Levashina
Oct 13, 2016·Annual Review of Genetics·Alvaro Molina-CruzCarolina Barillas-Mury
Sep 24, 2015·PLoS Biology·Julien Pompon, Elena A Levashina
Jul 7, 2017·Frontiers in Cellular and Infection Microbiology·Suzana Zakovic, Elena A Levashina
May 26, 2017·PloS One·Lauren M Childs, Olivia F Prosper
Jan 30, 2018·Frontiers in Cellular and Infection Microbiology·Constentin DiemeChristian Mitri
Dec 18, 2018·Frontiers in Immunology·Augustina FrimpongWilfred Ndifon

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