Genetic complexity of autoimmune myocarditis

Autoimmunity Reviews
Haiyan S LiN R Rose

Abstract

Autoimmune myocarditis, a chronic stage of myocardial inflammation, occurs in a small subset of patients after acute cardiotropic viral infection and can lead to dilated cardiomyopathy (DCM). This disease can be recapitulated in susceptible mouse strains by infection with coxsackievirus B3, or by immunization with cardiac myosin or cardiac troponin I. The etiologies of myocarditis are multifactorial and genetically complex. Genetic linkage between susceptibility to myocarditis/DCM and the major histocompatibility complex (MHC) genes has been reported in both humans and experimentally induced mouse models. However, unlike other autoimmune diseases, the non-MHC genes seem to have greater impact than MHC genes on disease susceptibility. Several myocarditis-related non-MHC loci have been identified by our laboratory and others in different models. Most of these loci overlap with other autoimmune disease susceptibility loci, suggesting common or shared genetic traits influencing general autoimmunity. For example, we have demonstrated that Eam1 and Eam2 may influence disease susceptibility via regulating T cell apoptosis at different developmental stages. Blockade of signaling through specific genes, such as CTLA4, ICOS and PD-1, can...Continue Reading

References

Nov 1, 1989·British Heart Journal·C J Limas, C Limas
Jan 1, 1986·Annals of the New York Academy of Sciences·N R RoseK W Beisel
Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·N D MeekerC Teuscher
Aug 1, 1993·Clinical Immunology and Immunopathology·S C Smith, P M Allen
Dec 7, 2000·The New England Journal of Medicine·M KamisagoC E Seidman
Feb 11, 2005·British Medical Bulletin·M J Simmonds, S C L Gough
Mar 24, 2005·Thyroid : Official Journal of the American Thyroid Association·Manuela Dittmar, George J Kahaly
Nov 15, 2006·Clinical and Experimental Immunology·E Z TchilianP C L Beverley
Nov 28, 2006·Experimental and Molecular Pathology·José Manuel Rodríguez-PérezGilberto Vargas-Alarcón

❮ Previous
Next ❯

Citations

Apr 1, 2009·Archivum Immunologiae Et Therapiae Experimentalis·Udi Nussinovitch, Yehuda Shoenfeld
Oct 15, 2009·Journal of Clinical Immunology·Noel R Rose
Aug 29, 2012·Current Treatment Options in Cardiovascular Medicine·Maya Guglin, Leelakrishna Nallamshetty
Dec 29, 2010·Clinical Reviews in Allergy & Immunology·Udi Nussinovitch, Yehuda Shoenfeld
Feb 11, 2010·European Journal of Human Genetics : EJHG·Volker RuppertUNKNOWN German Heart Failure Network
Jan 23, 2009·Journal of Gastroenterology·Andrea T BorchersM Eric Gershwin
Aug 3, 2012·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Arunakumar GangaplaraJay Reddy
Jun 21, 2011·Journal of Autoimmunity·Noel R Rose
Aug 3, 2010·Journal of Autoimmunity·Pierre Youinou
Oct 23, 2009·Journal of Autoimmunity·Kei MorohoshiSanta Jeremy Ono
Oct 6, 2009·Journal of Autoimmunity·J A ChioriniP Caturegli
Oct 13, 2009·Journal of Autoimmunity·Delisa Fairweather, Daniela Cihakova
Oct 9, 2009·Journal of Autoimmunity·Veena Taneja, Chella S David
Aug 18, 2009·Journal of Autoimmunity·Aftab A Ansari, M Eric Gershwin
Aug 18, 2009·Journal of Autoimmunity·Pietro Invernizzi, M Eric Gershwin
Apr 10, 2009·Journal of Autoimmunity·Pietro InvernizziMauro Podda
May 5, 2009·Journal of Autoimmunity·Pietro Invernizzi
Jan 16, 2008·Journal of Autoimmunity·Ian R MackayNoel R Rose
Sep 18, 2009·Annals of the New York Academy of Sciences·Maya C Poffenberger, Marc S Horwitz
Jul 11, 2012·Clinical and Experimental Immunology·P ChenD Cihakova
Dec 9, 2014·Journal of Theoretical Biology·Robert Root-Bernstein, DeLisa Fairweather
Jan 1, 2012·Case Reports in Cardiology·Thomas CognetMichel Galinier
Jul 3, 2013·Journal of Autoimmunity·Andrew H Lichtman
May 24, 2015·Cardiac Electrophysiology Clinics·A John BaksiSanjay K Prasad
Dec 20, 2011·Journal of Autoimmunity·Ilaria BianchiPietro Invernizzi
May 24, 2012·Autoimmunity Reviews·Sophie MavrogeniGeorge D Kitas
Jan 2, 2009·Advances in Immunology·Daniela Cihakova, Noel R Rose
Apr 1, 2010·Lupus·N R Rose
Sep 16, 2017·Circulation Research·Barry H Trachtenberg, Joshua M Hare
Jun 22, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Aiqun PanGuoliang Xu
Sep 5, 2018·Current Hypertension Reviews·Muhammad Ali ChaudhryMichael W Fong
May 12, 2016·Current Opinion in Rheumatology·Noel R Rose
May 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Haiyan S LiMehmet L Guler
Apr 6, 2019·European Heart Journal Supplements : Journal of the European Society of Cardiology·Antonio Cannata'Gianfranco Sinagra
Oct 19, 2017·Japanese Journal of Clinical Oncology·Kazuko TajiriIkuo Sekine
Nov 25, 2019·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Dana Razzano, John T Fallon
Oct 24, 2020·JACC. Clinical Electrophysiology·C Narasimhan, Muthiah Subramanian
Dec 23, 2020·The American Journal of Cardiology·Gianluca Di BellaGiovanni Donato Aquaro
Mar 4, 2021·Nature Reviews. Cardiology·Jana GruneMatthias Nahrendorf
May 8, 2021·Current Cardiology Reports·Chiara BaggioMarco Merlo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.