Genetic contribution to the variance of blood pressure and heart rate: a systematic review and meta-regression of twin studies

Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies
Biqi WangLiming Li

Abstract

The genetic contribution of blood pressure and heart rate (HR) varied widely between studies. Demographic factors such as ethnicity, age and/or sex might explain some of the heterogeneity. We performed a systematic review focusing on four phenotypes: systolic blood pressure (SBP), diastolic blood pressure (DBP), HR and pulse pressure (PP). Meta-regression was conducted to analyze potential factors in relation to SBP and DBP heritability. A total of 10,613 independent twins that came from 17 studies were included in the analysis. The weighted mean value of heritability for SBP and DBP was 0.54 (95% CIs: 0.48-0.60) and 0.49 (95% CIs: 0.42-0.56). Comparatively, three studies of HR and four studies of PP heritability were limited for the heterogeneity test. Meta-regression showed that, on average, SBP heritability with additive genes/unique environment (AE) model tend to have a higher heritability than additive genes/shared environment/unique environment (ACE) model (coefficient = 0.0947, p = .0142). A similar result was found for DBP as well. No other factors such as sex, age, ethnicity, publication year were significantly associated with heritability variance. Our study shows heritability estimates based on twin studies of both S...Continue Reading

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Citations

Sep 12, 2016·European Journal of Applied Physiology·Ineke NederendEco J C de Geus
Apr 8, 2017·PLoS Genetics·Tian GeJordan W Smoller
Jan 21, 2017·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Chunxiao LiaoLiming Li
Apr 30, 2020·International Journal of Behavioral Medicine·Aino I L SaarinenMirka Hintsanen
Apr 6, 2017·Human Molecular Genetics·Marten E van den BergPatricia B Munroe
Dec 4, 2019·European Journal of Preventive Cardiology·Constance XhaardNicolas Girerd

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