Genetic Contribution to Variation in Risk Taking: A Functional MRI Twin Study of the Balloon Analogue Risk Task

Psychological Science
Li-Lin RaoShu Li

Abstract

Excessive risk-taking behaviors have been implicated as a potential endophenotype for substance use disorders and psychopathological gambling. However, the genetic and environmental influences on risk taking and the risk-related brain activations remain unclear. This study investigated the heritability of risk taking and the genetic influence on individual variation in risk-related brain activation. The Balloon Analogue Risk Task was used to assess individuals' risk-taking behavior. In a sample of 244 pairs of young adult twins, we found that there was a moderate heritability (41%) of risk taking. Using voxel-level analysis, we found a moderate genetic influence on risk-related brain activation. We also found a moderate genetic correlation between risk-taking behavior and risk-related brain activation in the left insula, right striatum, and right superior parietal lobule in the active-choice condition. The present study provides important evidence for the genetic correlation between risk-taking behavior and risk-related brain activation.

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Citations

Aug 30, 2019·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Dandan BiJianxin Zhang
Apr 30, 2019·Social Cognitive and Affective Neuroscience·Yun WangYuan Zhou
Jan 29, 2021·Frontiers in Neuroscience·Halim I BaqapuriKlaus Mathiak
Aug 19, 2021·Behavior Research Methods·Jeff Coon, Michael D Lee
Sep 26, 2021·The European Journal of Neuroscience·Josh LeotaKyle Nash

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Software Mentioned

AFNI
R environment
MATLAB
R
Prime
OpenMx
Statistical Parametric Mapping ( SPM )
3dClustSim

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