Genetic contribution to waist-to-hip ratio in Mexican children and adolescents based on 12 loci validated in European adults

International Journal of Obesity : Journal of the International Association for the Study of Obesity
Michelle TurcotteD Meyre

Abstract

The prevalence of abdominal obesity in Mexican children has risen dramatically in the past decade. Genome-wide association studies (GWAS) for waist-to-hip ratio (WHR) performed predominantly in European descent adult  populations have identified multiple single-nucleotide polymorphisms (SNPs) with larger effects in women. The contribution of these SNPs to WHR in non-European children is unknown. Mexican children and adolescents (N = 1421, 5-17 years) were recruited in Mexico City. Twelve GWAS SNPs were genotyped using TaqMan Open Array and analyzed individually and as a gene score (GS). Mexican boys and girls displayed 2.81 ± 0.29 and 3.10 ± 0.31 WHR standard deviations higher than children and adolescents from the United States. WHR was positively associated with TG (β = 0.733 ± 0.190, P = 1.1 × 10-4) and LDL-C (β = 0.491 ± 0.203, P = 1.6 × 10-2), and negatively associated with HDL-C (β = -0.652 ± 0.195, P = 8.0 × 10-4), independently of body mass index. The effect allele frequency (EAF) of 8 of 12 (67%) SNPs differed significantly (P < 4.17 × 10-3) in Mexican children and European adults, with no evidence of effect allele enrichment in both populations (4 depleted and 4 enriched; binomial test, P = 1). Ten out of 12 SNPs (83....Continue Reading

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Methods Mentioned

BETA
PCR

Software Mentioned

GenABEL
HardyWeinberg
HuGE
R

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