PMID: 7138497Aug 1, 1982Paper

Genetic control of amino acid transport in sheep erythrocytes

Biochemical Genetics
J D YoungL Kilgour

Abstract

An inherited amino acid transport deficiency results in low concentrations of glutathione (GSH) in the erythrocytes of certain sheep. Earlier studies based on phenotyping according to GSH concentrations indicated that the gene TrH, which controls normal levels of GSH, behaves as if dominant or incompletely dominant to the allele Trh, which controls the GSH deficiency. The present papers shows that when sheep are classified according to amino acid transport activity, the TrH gene behaves as if codominant to Trh. Erythrocytes from sheep homozygous for the TrH gene exhibit rapid saturable L-alanine influx (apparent Km, 21.6 mM; Vmax, 22.4 mmol/liter cells/hr.). Cells from sheep homozygous for the Trh gene exhibit slow nonsaturable L-alanine uptake (0.55 mmol/liter cells/hr at 50mM extracellular L-alanine). Cells from heterozygous sheep show saturable L-alanine uptake with a diminished Vmax (apparent Km, 19.1 mM; Vmax, 12.7 mmol/liter cells/hr). These erythrocytes have a significantly lower GSH concentration than cells from TrH, TrH sheep but similar intracellular levels of dibasic amino acids.

References

Oct 1, 1978·Biochemical Genetics·S M Jarvis, J D Young
Jan 15, 1977·The Biochemical Journal·J D Young, J C Ellory
Sep 15, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·J D Young, P C Wright
Jan 15, 1976·The Biochemical Journal·J D YoungE M Tucker
Sep 26, 1980·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·J D YoungJ C Ellory

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Citations

Oct 1, 1983·Biochemical Genetics·E M TuckerJ D Young
Jan 1, 1987·The Journal of Membrane Biology·D A FinchamJ D Young
Mar 25, 2005·The British Journal of Nutrition·C Debier, Y Larondelle
Jan 1, 1985·Animal Blood Groups and Biochemical Genetics·E M Tucker, J D Young
Jan 1, 1989·Nutrition Reviews
Sep 3, 1984·Biochimica Et Biophysica Acta·S Bannai

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