PMID: 6975238Jan 1, 1981Paper

Genetic control of B- and T-lymphocyte abnormalities of NZB mice in crosses with B10.D2 mice

Immunogenetics
W F DavidsonH C Morse

Abstract

Parenteral NZB and B10.D2, F1 and F1 x B10.D2 mice were studied to determine the genetic control of (1) altered B-cell IgD expression, (2) plasma cell frequency, (3) IgM secretion per plasma cell, (4) primary in vitro cytotoxic T-cell responses to H-2-compatible cells, (5) production of thymocyte-binding antibodies, and (6) production of red-cell-specific antibodies. The results demonstrate that, in this cross, IgD abnormalities and production of red-cell-specific antibodies were recessive traits. There was a common genetic influence on plasma cell frequency, IgM secretion per plasma cell and production of thymocyte-binding antibodies which was distinct from the genes governing the ability to generate a cytotoxic T lymphocyte response to H-2-compatible cells.

References

Jan 1, 1977·Immunological Reviews·W F Davidson
Jan 1, 1977·Immunological Reviews·K J Lafferty, J Woolnough
May 1, 1978·The Journal of Experimental Medicine·E S RavechéJ H Tjio
Mar 15, 1974·Cellular Immunology·I O AuerF Milgrom
Apr 1, 1973·Clinical Immunology and Immunopathology·N L Warner
Jun 1, 1966·The Australian Journal of Experimental Biology and Medical Science·M C Holmes, F M Burnet
Apr 1, 1980·European Journal of Immunology·K F Lindahl, B Hausmann

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