PMID: 108678Mar 1, 1979

Genetic control of chromosome breakage and rejoining in Drosophila melanogaster: spontaneous chromosome aberrations in X-linked mutants defective in DNA metabolism

Proceedings of the National Academy of Sciences of the United States of America
M Gatti

Abstract

Eight X-linked recombination-defective meiotic mutants (representing five loci) and 12 X-linked mutagen-sensitive mutants (representing seven loci) of Drosophila melanogaster have been examined cytologically in neuroblast metaphases for their effects on the frequencies and types of spontaneous chromosome aberrations. Twelve mutants, representing five loci, significantly increase the frequency of chromosomal aberrations. The mutants at these five loci, however, differ markedly both in the types of aberrations produced and the localization of their effects along the chromosome. According to these criteria, the mutants can be assigned to four groups: (i) mutants producing almost exclusively chromatid breaks in both euchromatin and heterochromatin; (ii) mutants producing chromatid and isochromatid breaks in both euchromatin and heterochromatin; (iii) mutants producing chromatid mutants producing chromatid and isochromatid breaks clustered in the heterochromatin.

References

Jan 1, 1976·Annual Review of Genetics·B S BakerL Sandler
Nov 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·B S BakerP D Smith
Jan 1, 1977·Cytogenetics and Cell Genetics·Y Shiraishi, A A Sandberg
Jan 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·A R LehmannD Bootsma
Oct 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·S A LattP S Gerald
Jan 1, 1975·Annual Review of Genetics·J E Cleaver, D Bootsma
Nov 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·R S ChagantiJ German

Citations

Jan 1, 1985·Molecular & General Genetics : MGG·M A Narachi, J B Boyd
Jan 1, 1982·Molecular & General Genetics : MGG·J B Boyd, K E Shaw
Jan 1, 1989·Molecular & General Genetics : MGG·J M MasonA H Yamamoto
Apr 16, 1998·Mutation Research·P G de Buendía
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·M GattiB S Baker
Sep 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·R K MortimerD Schild
Oct 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·A T Carpenter
Feb 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·B S BakerM Gatti
Aug 28, 2003·Journal of Anti-aging Medicine·R C Woodruff, J N Thompson
Oct 7, 2003·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Sonia Symphorien, R C Woodruff
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·R G SargentR S Nairn
Oct 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Xiaolin BiYikang S Rong
Mar 13, 2014·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Manish MishraD Kar Chowdhuri
Sep 1, 1988·International Journal of Radiation Biology·J S Rubin

Related Concepts

Autosome Abnormalities
DNA, Double-Stranded
Base Excision Repair
Drosophila melanogaster
M Phase, Meiotic
M Phase, Mitotic
Recombination, Genetic
Sex Chromosomes
X Chromosome

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