PMID: 7007877Dec 1, 1980Paper

Genetic control of diploid recovery after gamma-irradiation in the yeast Saccharomyces cerevisiae

Mutation Research
T SaekiS Nakai

Abstract

Genetic mechanisms(s) of gamma-ray resistance of the diploid and budding haploid cells of S. cerevisiae were investigated, with special reference to mitotic recombination, by examining 11 rad mutant strains. The radiosensitivity of the diploid was markedly enhanced in certain gamma-ray-sensitive rad mutants, whereas the sensitivity of the haploid was not so enhanced in these rad mutants. These enhanced sensitivities of diploids were irrespective of their own haploid sensitivities. From these results, the existence of a mechanism of diploid-specific recovery was postulated. The magnitude of diploid radioresistance in rad mutants was positively correlated with the ability for the induction of mitotic recombinational events which were controlled by RAD genes belonging to the RAD-51 genetic pathway. The genetic mechanism(s) of the diploid recovery after gamma-irradiation are probably related to recombinational processes between the homologous chromosomes leading to reciprocal recombination or non-reciprocal gene conversion. Furthermore, the higher radioresistance of budding cells in comparison with the non-budding cells was also correlated to the diploid radioresistance with a few exceptions. Consequently, the mechanism(s) of buddi...Continue Reading

References

Dec 1, 1977·Molecular Biology Reports·A N LuchnikS V Shestakov
Dec 14, 1977·Molecular & General Genetics : MGG·M A Hannan, A Nasim
Jan 16, 1976·Molecular & General Genetics : MGG·M A Resnick, P Martin
Feb 1, 1976·Genetics·C W Lawrence, R Christensen
Aug 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·W R Boram, H Roman
Aug 1, 1974·Mutation Research·B Cox, J Game
Sep 1, 1974·Mutation Research·J C Game, R K Mortimer
Mar 1, 1967·Mutation Research·S Nakai, S Matsumoto
Sep 1, 1967·Journal of Bacteriology·R Snow
Mar 1, 1954·Archives of Biochemistry and Biophysics·C A BEAMC A TOBIAS
Aug 1, 1960·Experimental Cell Research·D H WILLIAMSON, A W SCOPES

❮ Previous
Next ❯

Citations

Jan 1, 1981·Molecular & General Genetics : MGG·V G Petin, V L Matrenina
Aug 1, 1995·Current Genetics·O V ChepurnayaV G Korolev
Jan 1, 1984·Molecular & General Genetics : MGG·F FabreH Roman
Jan 1, 1983·Molecular & General Genetics : MGG·S L KellyJ M Parry
Jan 1, 1985·Molecular & General Genetics : MGG·C I White, S G Sedgwick
Jun 1, 1989·Molecular & General Genetics : MGG·H H de AndradeJ A Henriques
Feb 22, 1982·Mutation Research·W DezzaniJ B Boyd
Jul 1, 1985·Mutation Research·N J Sargentini, K C Smith
May 29, 2004·Mutation Research·Andrej Dudás, Miroslav Chovanec
Oct 7, 2003·International Journal for Parasitology·Mrinal Kanti Bhattacharyya, Nirbhay Kumar
Aug 1, 2000·Mutation Research·L K Lewis, M A Resnick
Aug 1, 2000·Mutation Research·J C Game
Feb 9, 2006·Chemical Reviews·David M NollPaul S Miller
Jun 10, 1998·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·A ShinoharaT Ogawa
Nov 9, 2000·The Plant Journal : for Cell and Molecular Biology·M HaninJ Paszkowski

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.