PMID: 6409816Aug 15, 1983Paper

Genetic control of immune responses to Moloney sarcomas in rats: role of non-RT-1 background genes

International Journal of Cancer. Journal International Du Cancer
J M Jones

Abstract

Bone marrow chimeras, athymic nude rats and a congeneic strain were utilized to verify and further examine non-RT-1 linked background genes that influence immune responses of BN and LEW rats to Moloney sarcomas. In transplants that did not involve RT-1 incompatibility, infusion of high-responder bone marrow into a lethally irradiated low-responder recipient, or low-responder bone marrow into a high-responder recipient, would restore a high antibody response to the gp70 antigen of MuLV. Such transplants did not restore a high response to the p30 antigen. Athymic nude rats did not exhibit a significant response to either p30 or gp70 while euthymic littermates exhibited a significant response to both antigens. Growth of Moloney sarcomas as well as antibody and cellular responses to antigens expressed by such tumors were measured in LEW-IN rats which carry the RT-1 of BN and the background of LEW. For each of these parameters, LEW-IN resembled LEW more closely than BN.

References

Oct 1, 1975·Journal of the National Cancer Institute·J M Jones, J D Feldman
Jan 1, 1977·Annual Review of Genetics·R Steeves, F Lilly
Jun 1, 1978·Journal of the National Cancer Institute·J M JonesJ D Feldman
May 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·H von BoehmerN K Jerne
Jan 1, 1977·International Journal of Cancer. Journal International Du Cancer·B C VeitJ D Feldman
Jun 1, 1974·Journal of the National Cancer Institute·J M JonesJ D Feldman
May 1, 1982·The Journal of Experimental Medicine·P A Berche, R J North
Jan 1, 1982·Leukemia Research·J M JonesF B Soderberg
Dec 1, 1978·Immunogenetics·D L GasserG Balaban-Malenbaum

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