PMID: 8590345Nov 1, 1995Paper

Genetic control of indirect airway responsiveness in the rat

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
R A PauwelsG F Joos

Abstract

Many of the airway responses to endogenous and exogenous stimuli are caused by indirect mechanisms such as the activation of neurons and/or inflammatory cells. In the present study we compare the bronchoconstrictor and the plasma protein extravasation response to adenosine and tachykinins in two highly inbred rat strains, F344 and BDE. BDE-rats have a bronchoconstrictor response to adenosine at lower doses. Challenge with the A3-adenosine receptor agonist APNEA demonstrates that the difference in airway responsiveness to adenosine between BDE- and F344-rats is probably related to a higher number of A3-receptors on the airway mast cells of BDE-rats. In contrast, F344-rats have a higher airway responsiveness to tachykinins than BDE-rats. Tachykinins cause bronchoconstriction in F344-rats mainly by an indirect mechanism, involving stimulation of NK1-receptors and mast cell activation. In BDE-rats they cause bronchoconstriction by a direct effect on airway smooth muscle via activation of NK2-receptors. Finally we also observed a difference between F344- and BDE-rats with regard to the mechanisms involved in the plasma protein extravasation in the airways caused by substance P or capsaicin. In F344-rats but not in BDE-rats mast cell...Continue Reading

References

Feb 7, 1992·Journal of Medicinal Chemistry·K A JacobsonM Williams
May 1, 1988·The American Review of Respiratory Disease·G F JoosM E van der Straeten
Aug 1, 1987·The American Review of Respiratory Disease·R A Pauwels, M E Van der Straeten
Nov 1, 1981·The Journal of Allergy and Clinical Immunology·F E HargreaveJ Dolovich
Oct 1, 1993·Trends in Pharmacological Sciences·M G Collis, S M Hourani

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Citations

Jan 1, 1996·Drug Development Research·I Feoktistov, I Biaggioni
Jun 6, 2013·British Journal of Pharmacology·A C Rosa, R Fantozzi
May 5, 2012·European Journal of Pharmacology·Tatsuo SakamotoMio Miyake
Dec 22, 1999·The American Journal of Physiology·G T De SanctisJ M Drazen

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