PMID: 7031649Oct 1, 1981Paper

Genetic control of insulin receptors

Proceedings of the National Academy of Sciences of the United States of America
A E GoldfeldS Gluecksohn-Waelsch

Abstract

Insulin-binding activity was measured in hepatocyte suspensions and liver membrane preparations from newborn mice homozygous for a perinatal-lethal deletion at and around the albino locus in chromosome 7. Cell suspensions and membrane preparations from the mutant mice exhibited only 20-25% of the specific hormone-binding activity observed in comparable preparations from their homozygous normal and heterozygous littermates. The decrease in insulin-binding activity appears to be attributable to a decrease in the number of insulin receptor sites per cell rather than to a change in receptor affinity. Gene sequences deleted at and around the albino locus are therefore instrumental in the regulation of insulin receptor concentration rather than in coding for the insulin receptor itself. The results of the present studies extend the identification of the regulatory functions exerted by the genes around the albino locus of the mouse.

References

Oct 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·R C GarlandC F Cori
Aug 23, 1979·Biochimica Et Biophysica Acta·E E SchillingF L Crane
Oct 27, 1977·The New England Journal of Medicine·A V Thorsson, R L Hintz
Feb 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·R P EricksonC F Cori
Oct 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·A Amsterdam, J D Jamieson
Jan 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·C F CoriH F Wang-Chang

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Citations

Jan 1, 1992·Mammalian Genome : Official Journal of the International Mammalian Genome Society·M L KlebigE M Rinchik
Sep 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·P A Shaw, S Gluecksohn-Waelsch
Mar 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·A E GoldfeldS Gluecksohn-Waelsch
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·L J BaierR P Erickson
Jan 1, 1982·Endocrine Research Communications·A AmadorW Beamer
Jan 1, 1983·Transactions of the New York Academy of Sciences·S Gluecksohn-Waelsch

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