No abstract listed.
Relationship of sulfamethazine disposition kinetics to acetylator phenotype in man. A preliminary study
Predominance of slow acetylators of N-acetyltransferase in a Hmong population residing in the United States
Urinary methylchloroform rather than urinary metabolites as an indicator of occupational exposure to methylchloroform
The relationship between acetylator status and inhibition of monoamine oxidase, excretion of free drug and antidepressant response in depressed patients on phenelzine
Characterization of human lymphocyte N-acetyltransferase and its relationship to the isoniazid acetylator polymorphism
Distribution of acetylator phenotype in relation to age and sex in Swedish patients. A retrospective study
Effect of concomitant isoniazid administration on determination of acetylator phenotype by sulphadimidine
Lack of effect of the appetite stimulant pizotifen (BC 105) on the absorption of isonicotinylhydrazine
Human acetylator genotype: relationship to colorectal cancer incidence and arylamine N-acetyltransferase expression in colon cytosol
Prediction of phenotype for acetylation and for debrisoquine hydroxylation by DNA-tests in healthy human volunteers
Glucose-6-phosphate dehydrogenase deficiency and sulfadimidin acetylation phenotypes in Egyptian oases
Genetic and metabolic risk factors for the development of late complications in type I (insulin-dependent) diabetes
Association between chlorpropamide-alcohol flushing and fast acetylator phenotype in type I and type II diabetes
Determination of N-acetylation phenotyping in a Greek population using caffeine as a metabolic probe
Exploring warfarin pharmacogenomics with the extreme-discordant-phenotype methodology: impact of FVII polymorphisms on stable anticoagulation with warfarin
Is there any difference between acetylator phenotypes in tuberculosis patients and healthy subjects?
NAT2 genotype guided regimen reduces isoniazid-induced liver injury and early treatment failure in the 6-month four-drug standard treatment of tuberculosis: a randomized controlled trial for pharmacogenetics-based therapy.
Identification of arylamine N-acetyltransferase inhibitors as an approach towards novel anti-tuberculars
Demonstration of slow acetylator genotype of N-acetyltransferase in isoniazid neuropathy using an archival hematoxylin and eosin section of a sural nerve biopsy specimen
Determination of the acetylator phenotype from the ratio of the urinary excretion of acetylisoniazid to acid-labile isoniazid: a study in Finnish Lapland
Idiosyncratic reactions to antidepressants: a review of the possible mechanisms and predisposing factors
Purification and partial characterization of chicken liver acetyl coenzyme A: arylamine N-acetyltransferase
Possible ethnic difference in toluene metabolism: a comparative study among Chinese, Turkish and Japanese solvent workers
Pharmacogenetic aspects in the metabolism of psychotropic drugs: pharmacokinetic and clinical implications
The structure of arylamine N-acetyltransferase from Mycobacterium smegmatis--an enzyme which inactivates the anti-tubercular drug, isoniazid
Structural investigation of mutant Mycobacterium smegmatis arylamine N-acetyltransferase: a model for a naturally occurring functional polymorphism in Mycobacterium tuberculosis arylamine N-acetyltransferase
Analysis of nucleotide diversity of NAT2 coding region reveals homogeneity across Native American populations and high intra-population diversity
HEREDITARY TRANSMISSION OF EXCEPTIONAL RESISTANCE TO COUMARIN ANTICOAGULANT DRUGS. THE FIRST REPORTED KINDRED
Effect of acetylator phenotype on the rate at which procainamide induces antinuclear antibodies and the lupus syndrome
Relationship between the genetically determined acetylator phenotype and DNA damage induced by hydralazine and 2-aminofluorene in cultured rabbit hepatocytes
Isolation of enzyme cDNA clones by enzyme immunodetection assay: isolation of a peptide acetyltransferase
N-acetylation pharmacogenetics: a gene deletion causes absence of arylamine N-acetyltransferase in liver of slow acetylator rabbits
Arylamine N-acetyltransferase is required for synthesis of mycolic acids and complex lipids in Mycobacterium bovis BCG and represents a novel drug target
Human arylamine N-acetyltransferase genes: isolation, chromosomal localization, and functional expression
Risk assessment and communication tools for genotype associations with multifactorial phenotypes: the concept of "edge effect" and cultivating an ethical bridge between omics innovations and society
Meta-analysis of clinical studies supports the pharmacokinetic variability hypothesis for acquired drug resistance and failure of antituberculosis therapy
Lack of correlation between acetylator status and the production of the acetyl metabolite of acebutolol in man
Simultaneous analysis of dapsone and monoacetyldapsone employing high performance liquid chromatography: a rapid method for determination of acetylator phenotype
The N-acetyltransferase (NAT) gene: an early risk marker for diabetic nephropathy in Japanese type 2 diabetic patients?
Identification and characterization of functional rat arylamine N-acetyltransferase 3: comparisons with rat arylamine N-acetyltransferases 1 and 2
Codominant expression of N-acetylation and O-acetylation activities catalyzed by N-acetyltransferase 2 in human hepatocytes
Isoniazid bactericidal activity and resistance emergence: integrating pharmacodynamics and pharmacogenomics to predict efficacy in different ethnic populations
An oracle: antituberculosis pharmacokinetics-pharmacodynamics, clinical correlation, and clinical trial simulations to predict the future
Inhibition of cytochrome P450 (CYP450) isoforms by isoniazid: potent inhibition of CYP2C19 and CYP3A
Sulphadimidine acetylation test for classification of patients as slow or rapid inactivators of isoniazid
Partial purification and properties of the isoniazid transacetylase in human liver. Its relationship to the acetylation of p-aminosalicylic acid
Genetic and environmental factors that regulate cytosolic epoxide hydrolase activity in normal human lymphocytes
Acetylation pharmacogenetics. The slow acetylator phenotype is caused by decreased or absent arylamine N-acetyltransferase in human liver
Genetic variability and extrapolation from animals to man: some perspectives on susceptibility to chemical carcinogenesis from aromatic amines
The differential effect of NAT2 variant alleles permits refinement in phenotype inference and identifies a very slow acetylation genotype
Pharmacogenomics and "individualized drug therapy": high expectations and disappointing achievements
Accuracy of various human NAT2 SNP genotyping panels to infer rapid, intermediate and slow acetylator phenotypes
N-acetylation of p-amino-hippurate in kidneys with renal artery stenosis and in patients suffering from severe essential hypertension
Comparison of the Arylamine N-acetyltransferase from Mycobacterium marinum and Mycobacterium tuberculosis
From human genetics and genomics to pharmacogenetics and pharmacogenomics: past lessons, future directions
Role of single nucleotide polymorphisms in pharmacogenomics and their association with human diseases
Crystal structure of arylamine N-acetyltransferases: insights into the mechanisms of action and substrate selectivity
Clinical pharmacokinetics: current requirements and future perspectives from a regulatory point of view
Folate-Dependent Hydrolysis of Acetyl-Coenzyme A by Recombinant Human and Rodent Arylamine N-Acetyltransferases
Functional and structural characterization of the arylamine N-acetyltransferase from the opportunistic pathogen Nocardia farcinica
Variation in NAT2 acetylation phenotypes is associated with differences in food-producing subsistence modes and ecoregions in Africa
Genetic polymorphisms of drug-metabolizing phase I enzymes CYP2E1, CYP2A6 and CYP3A5 in South Indian population
Treating individuals 2. Subgroup analysis in randomised controlled trials: importance, indications, and interpretation
The effect of diabetes on the in vivo acetylation capacity of the spontaneously diabetic, insulin-dependent BB/Edinburgh Wistar rat
The potential clinical significance of the isoniazid acetylator phenotype in the treatment of pulmonary tuberculosis
The determination of the acetylator phenotype of tuberculosis patients in Czechoslovakia using sulphadimidine
Classification of subjects as slow or rapid inactivators of isoniazid, based on the ratio of the urinary excretion of acetylisoniazid to isoniazid
Genetically-determined interaction between propafenone and low dose quinidine: role of active metabolites in modulating net drug effect
Isoniazid disposition, comparison of isoniazid phenotyping methods in and acetylator distribution of Japanese patients with idiopathic systemic lupus erythematosus and control subjects
Drug metabolism and pharmacogenetics: the British contribution to fields of international significance
Isoniazid-induced polyneuropathy in a tuberculosis patient - implication for individual risk stratification with genotyping?
N-acetyltransferase activity in the urine in Japanese subjects: comparison in healthy persons and bladder cancer patients
Rapid identification of the NAT2 genotype in tuberculosis patients by multicolor melting curve analysis
Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione-S-transferase, and epoxide hydrolase enzymes: relevance to xenobiotic metabolism and toxicity
New spectrophotometric and radiochemical assays for acetyl-CoA: arylamine N-acetyltransferase applicable to a variety of arylamines
A STUDY OF THE INFLUENCE OF THE ISONIAZID INACTIVATOR PHENOTYPE ON REVERSION IN GENITO-URINARY TUBERCULOSIS
The convergence of conventional therapeutic drug monitoring and pharmacogenetic testing in personalized medicine: focus on antidepressants
The clinical effectiveness and cost-effectiveness of cetuximab (review of technology appraisal no. 176) and panitumumab (partial review of technology appraisal no. 240) for previously untreated metastatic colorectal cancer: a systematic review and economic evaluation
Arylamine N-acetyltransferase of Mycobacterium tuberculosis is a polymorphic enzyme and a site of isoniazid metabolism
Generation and analysis of mice with a targeted disruption of the arylamine N-acetyltransferase type 2 gene
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients
Mycobacterium tuberculosis Arylamine N-Acetyltransferase Acetylates and Thus Inactivates para-Aminosalicylic Acid
Genetics of a difference in the male genitalia of east and west African stocks of Papilio dardanus (Lep.)
The use of cells from rat, mouse, hamster, and rabbit in the hepatocyte primary culture/DNA-repair test
The Influence of Pharmacogenetic Variants in HIV/Tuberculosis Coinfected Patients in Uganda in the SOUTH Study
Hydralazine-induced relapsing polychondritis-like syndrome. Report of a case with severe chronic laryngeal complications
N-acetyltransferase 2 genotyping: an accurate and feasible approach for simultaneous detection of the most common NAT2 alleles
Single nucleotide polymorphism coverage and inference of N-acetyltransferase-2 acetylator phenotypes in wordwide population groups
NAT2*5/*5 genotype (341T>C) is a potential risk factor for schistosomiasis-associated bladder cancer in Egyptians
N-Acetyltransferase 2 Genotypes among Zulu-Speaking South Africans and Isoniazid and N-Acetyl-Isoniazid Pharmacokinetics during Antituberculosis Treatment.
Acetylator phenotype and metabolic disposition of isoniazid in Japanese patients with systemic lupus erythematosus
Evaluation of the sulphapyridine acetylator phenotyping test in healthy subjects and in patients with cardiac and renal diseases
Microarray expression profile analysis of mRNAs and long non-coding RNAs in pulmonary tuberculosis with different traditional Chinese medicine syndromes
Mass spectrometry of blood low-molecular fraction as a method for unification of therapeutic drug monitoring
Expression, purification, characterization and structure of Pseudomonas aeruginosa arylamine N-acetyltransferase
Relationship between N-acetyltransferase (NAT) activity and liver protoporphyrin level in experimental porphyria
The Role of N-Acetyl Transferases on Isoniazid Resistance from Mycobacterium tuberculosis and Human: An In Silico Approach
Further evidence for the lack of association between acetylator phenotype and systemic lupus erythematosus
Study of NAT2 gene polymorphisms in an Indian population: association with plasma isoniazid concentration in a cohort of tuberculosis patients
Arylarnine N-acetyltransferase as a potential biornarker in bladder cancer: fluorescent in situ hybridization and irnmunohistochernistry studies
Importance of Publishing Adverse Drug Reaction Case Reports: Promoting Public Health and Advancing Pharmacology and Therapeutics
Translating Pharmacogenetics and Pharmacogenomics to the Clinic: Progress in Human and Veterinary Medicine
Is IQG-607 a Potential Metallodrug or Metallopro-Drug With a Defined Molecular Target in Mycobacterium tuberculosis ?
Arylamine N-acetyltransferase acetylation polymorphisms: paradigm for pharmacogenomic-guided therapy- a focused review.
Cloning and characterization of arylamine N-acetyltransferase genes from Mycobacterium smegmatis and Mycobacterium tuberculosis: increased expression results in isoniazid resistance
Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.
Evolution of Pluripotency
Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.
Lipidomics & Rhinovirus Infection
Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.
Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.
Chronic Fatigue Syndrome
Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.
Alzheimer's Disease: MS4A
Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.
STING Receptor Agonists
Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.
Laryngeal Neoplasms occur in the Larynx and are typically associated with smoking and alcohol consumption. Discover the latest research on Laryngeal Neoplasms here.
Cell Atlas Along the Gut-Brain Axis
Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.