Genetic control of lysine permeases in Saccharomycopsis lipolytica

Archives of Microbiology
J M BeckerichH Heslot

Abstract

In order to obtain strains of Saccharomycopsis lipolytica impaired in the active transport of L-lysine, mutants resistant to a mixture of L-canavanine, L-4-5-transdehydrolysine and L-S-amino ethylcysteine, taken either all three or two by two, were isolated. These compounds were shown previously to be competitive inhibitors of L-lysine uptake. The resistance patterns and excretion capacity of the mutants were established. All mutants behaved as monogenic. Recombination tests indicated that four genes at least were involved. All mutants were impaired in both high and low affinity L-lysine transport systems. Several hypotheses on the functions of these genes are put forward and discussed.

References

Feb 1, 1978·Journal of Bacteriology·J M Beckerich, H Heslot
Jan 1, 1975·Journal of General Microbiology·J R Kinghorn, J A Pateman
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Jan 1, 1973·Archiv für Mikrobiologie·C M GaillardinH Heslot
Oct 1, 1971·Journal of Bacteriology·J BasselR Mortimer
Feb 20, 1970·Science·L J WickerhamA I Herman

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Citations

Dec 22, 1986·Biochimica Et Biophysica Acta·J Horák
Jan 1, 1985·Critical Reviews in Microbiology·J K Bhattacharjee
Jul 1, 1982·Molecular and Cellular Biology·M A DelgadoJ Conde

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