Genetic control of natural resistance to nontuberculous mycobacterial infections in mice.

Infection and Immunity
I M OrmeF M Collins

Abstract

Results show that various inbred strains of mice can be segregated into two distinct groups, based on their capacity to allow a number of nontuberculous mycobacterial infections to grow in target organs following experimental intravenous infection. The first group, which allowed these infections to grow progressively, was thus designated as naturally susceptible to these infections; in contrast, those strains which were able to exert detectable bacteriostasis were designated as naturally resistant. It was then found that segregation of mouse strains based on this distinction also mirrored the capacity of these animals to generate acquired immunity to the mycobacterial infections. For example, Mycobacterium simiae grew progressively in susceptible C57BL/6 mice, subsequently triggering acquired mechanisms of immunity, whereas no evidence for acquired immunity could be found in resistant A/Tru mice infected with this organism. The possibility that acquired immunity could not be expressed in the latter strain as a result of a defect in macrophage activation was excluded. Moreover, it was found that the trait of resistance to these infections could be transferred by bone marrow cells into radiation chimeras, thus indicating that thi...Continue Reading

Citations

Jul 1, 1990·Clinical and Experimental Immunology·R W Stokes, F M Collins
Jan 1, 1988·Springer Seminars in Immunopathology·F M Collins
Mar 26, 2003·The Journal of Small Animal Practice·U DietrichB Spiess
Mar 1, 1992·Clinical and Experimental Immunology·R Appelberg, J Pedrosa
Feb 22, 2012·Cellular Microbiology·Dmitriy IgnatovAlexander Apt
Aug 1, 2007·Infection and Immunity·E V KondratievaA S Apt
Jun 11, 2014·Infection and Immunity·Ian M Orme, Diane J Ordway
Jul 1, 1993·Clinical Microbiology Reviews·C B InderliedL E Bermudez
Nov 1, 1991·Infection and Immunity·Y YamamotoH Tomioka
Oct 1, 1989·Clinical Microbiology Reviews·F M Collins
Oct 1, 1994·Infection and Immunity·S B MarleyD Wakelin
Oct 12, 2016·Microbiology Spectrum·Ian M Orme, Diane J Ordway
Jan 1, 1992·Infection and Immunity·R D HubbardF M Collins

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