Genetic control of non-genetic inheritance in mammals: state-of-the-art and perspectives.

Mammalian Genome : Official Journal of the International Mammalian Genome Society
A Tomar, R Teperino

Abstract

Thought to be directly and uniquely dependent from genotypes, the ontogeny of individual phenotypes is much more complicated. Individual genetics, environmental exposures, and their interaction are the three main determinants of individual's phenotype. This picture has been further complicated a decade ago when the Lamarckian theory of acquired inheritance has been rekindled with the discovery of epigenetic inheritance, according to which acquired phenotypes can be transmitted through fertilization and affect phenotypes across generations. The results of Genome-Wide Association Studies have also highlighted a big degree of missing heritability in genetics and have provided hints that not only acquired phenotypes, but also individual's genotypes affect phenotypes intergenerationally through indirect genetic effects. Here, we review available examples of indirect genetic effects in mammals, what is known of the underlying molecular mechanisms and their potential impact for our understanding of missing heritability, phenotypic variation. and individual disease risk.

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Citations

Jul 10, 2020·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Johannes BeckersMartin Hrabé de Angelis
Jan 29, 2021·Journal of Molecular Biology·Federico ZambelliGraziano Pesole
Jun 24, 2021·Biology of Reproduction·Sean M CullenMatthew Smith-Raska

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