PMID: 6107905Jul 1, 1980Paper

Genetic control of number of midbrain dopaminergic neurons in inbred strains of mice: relationship to size and neuronal density of the striatum

Proceedings of the National Academy of Sciences of the United States of America
H BakerD J Reis

Abstract

The activity of tyrosine hydroxylase [TyrHase; tyrosine-3-monooxygenase; L-tyrosine, tetrahydropteridine: oxygen oxidoreductase (3-hydroxylating), EC 1.14.16.2] is 20% less in whole midbrain of CBA/J mice than BALB/cJ mice and is paralleled by a comparable difference in the number of dopaminergic neurons in which the enzyme can be detected immunocytochemically. The strain-dependent difference in numbers of TyrHase-containing neurons and of TyrHase activity is not homogeneous in the midbrain but is restricted (along the rostral-caudal axis) to the medial one-third, where almost 2-fold variations are found. The volume of the striatum, a major projection field of midbrain dopamine neurons, is 20% smaller in CBA/J than in BALB/cJ mice; the difference is regional and is concentrated in the caudal half. Because the packing density of intrinsic neurons of the striatum is similar in both strains, CBA/J mice contain 20% fewer neurons than do BALB/cJ mice. The activities of TryHase and of choline acetyltransferase (ChoAcTase; acetyl-CoA:choline-O-acetyltransferase, EC 2.3.1.6) in the whole striatum of CBA/J mice are less than in BALB/cJ. The strain-dependent differences in midbrain TyrHase activity are due to variations in the number of ...Continue Reading

References

Jul 1, 1976·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·V M PickelD J Reis
Jan 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·G TeitelmanD J Reis
Jan 1, 1978·Annual Review of Neuroscience·R Y Moore, F E Bloom
Jun 15, 1972·Life Sciences. Pt. 1: Physiology and Pharmacology·R D CiaranelloJ D Barchas
Oct 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·T H JohD Reis
Feb 1, 1972·Behavioral Biology·D S SegalA J Mandell
Apr 26, 1974·Brain Research·B E Eleftheriou
May 10, 1974·Brain Research·S G Butcher, L L Butcher
Oct 1, 1967·Journal of Neurochemistry·B K Schrier, L Shuster

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Citations

Jul 25, 2000·The Journal of Comparative Neurology·V Jackson-LewisS Przedborski
Apr 16, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·O BandmannN W Wood
Nov 1, 1994·Mammalian Genome : Official Journal of the International Mammalian Genome Society·C VadászR Zahorchak
Oct 1, 1992·Amino Acids·C VadaszA Fleischer
Aug 1, 1986·Neurochemical Research·C VadászA Lajtha
Feb 1, 1982·Behavior Genetics·D R PetersenR G Miles
Jul 1, 1996·Mammalian Genome : Official Journal of the International Mammalian Genome Society·C VadászR Zahorchak
Aug 5, 1985·Brain Research·J A Severson
Mar 22, 1988·Brain Research·I DivacA Björklund
Sep 1, 1991·Pharmacology, Biochemistry, and Behavior·H E ShannonS C Peters
Apr 1, 1993·Pharmacology, Biochemistry, and Behavior·E M Nikulina, V Klimek
Sep 1, 1993·Brain Research. Brain Research Reviews·T E Robinson, K C Berridge
Dec 1, 1982·Psychiatry Research·D M Helmeste, P Seeman
Jun 14, 1996·Brain Research. Developmental Brain Research·K LiebC Pilgrim
Jan 1, 1984·Progress in Neurobiology·J J Feigenbaum, J Yanai
Sep 1, 1986·Neuroscience·P J May, W C Hall
Jan 1, 1987·Psychoneuroendocrinology·D G MorganP K Randall
Jan 1, 1987·Brain Research Bulletin·I SzirákiC Vadász
May 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·R E Boehme, R D Ciaranello
Jul 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·P Levitt, J L Noebels
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·L C TriarhouB Ghetti
Sep 19, 2008·Development·Niva Russek-BlumGil Levkowitz
Jul 6, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·C Savio ChanD James Surmeier
Mar 13, 2010·International Journal of Biological Sciences·Amy M Knab, J Timothy Lightfoot
Mar 15, 2006·Apoptosis : an International Journal on Programmed Cell Death·D A DorseyG A de Erausquin
Feb 10, 2016·Journal of Chemical Neuroanatomy·YuHong FuGlenda M Halliday
Oct 1, 2008·Journal of Neurochemistry·Patricia Marques PereiraAndré Hanauer

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