PMID: 8587794Jan 1, 1996Paper

Genetic control of susceptibility to Taenia crassiceps cysticercosis

Parasitology
G FragosoE Sciutto

Abstract

We previously reported that genes within the major histocompatibility complex influence the intensity of Taenia crassiceps murine cysticercosis. This genetic control, readily apparent in mice of BALB background, was further studied in H-2 congenic and recombinant B10 mice as well as in BALB/c substrains differing in expression of Qa-2 antigens. Similarly low parasite numbers were found in all B10-derived strains infected, regardless of H-2 haplotype, indicating that the effect of H-2 genes in controlling susceptibility is overridden in mice of B10 background. BALB/c substrains differed significantly in susceptibility. BALB/cAnN was highly susceptible, whereas BALB/cJ, in contrast, was highly resistant and BALB/cByJ showed intermediate susceptibility. Susceptibility or resistance in BALB/c substrains may be associated to differences known to distinguish them, such as serum testosterone levels and Qa-2 protein expression. In bidirectional F1 hybrids of C57BL/6J and BALB/cAnN resistance to cysticercosis was inherited as a dominant autosomal trait. In F1 hybrids of BALB/cJ with BALB/cAnN, BALB/cByJ and BALB.K resistance was also inherited as a dominant trait. However, in (BALB/cAnN x BALB/cByJ)F1 and (BALB/cAnN x BALB.K)F1 hybrids,...Continue Reading

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Citations

Dec 1, 2005·Transactions of the Royal Society of Tropical Medicine and Hygiene·A FleuryE Sciutto
Jun 11, 2002·Experimental Parasitology·Tamio OhnoMamoru Terada
Oct 20, 2009·Parasitology·Kaethe Willms, Rimma Zurabian
Dec 30, 2011·PLoS Neglected Tropical Diseases·Ruben Ramirez-AquinoIrma Aguilar-Delfin
Feb 16, 2013·The Journal of Parasitology·Edda SciuttoCarlos Larralde
Jun 2, 2005·Neurosurgical Focus·Benedito Oscar ColliJoão Alberto Assirati
Jun 5, 2003·Parasitology Research·Sergio López-BrionesEdda Sciutto
Apr 18, 2007·The Journal of Parasitology·Jerry R AldridgeR E Kuhn
Jan 9, 2007·Parasitology Research·Javier Alonso-TrujilloLuis I Terrazas
Aug 30, 2008·Research in Veterinary Science·Shih-Yi PengPing-Chin Fan
Sep 6, 2012·Evolution; International Journal of Organic Evolution·Stuart J E BairdJoëlle Goüy de Bellocq
Mar 23, 2005·Vaccine·Edda SciuttoFernando A Goldbaum
Jan 1, 2014·Experimental Parasitology·Emanuelle B GasparElizabeth De Gaspari
Sep 6, 2012·Experimental Parasitology·Wilai SaksirisampantBenjamas Wongsatayanon Thanomsub
Jul 3, 2016·Immunogenetics·Courtney K Anderson, Laurent Brossay
Nov 7, 2001·The Journal of Parasitology·G FragosoE Lamoyi
Mar 15, 2019·PLoS Neglected Tropical Diseases·Sandra PalmaUNKNOWN Cysticercosis Working Group in Peru
Nov 1, 2020·World Neurosurgery·Kanwaljeet GargPoodipedi Sarat Chandra
May 1, 2021·Frontiers in Cellular and Infection Microbiology·Laura Adalid-PeraltaEdgar E Sevilla-Reyes

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