Genetic control of susceptibility to hydroxyproline in Drosophila

Canadian Journal of Genetics and Cytology. Journal Canadien De Génétique Et De Cytologie
E W Rapport

Abstract

Hydroxyproline (OHP) is known to produce morphological abnormalities in susceptible Drosophila. In some, OHP prevents head eversion during pupation producing a cryptocephal (crc) phenocopy, others fail to fully stretch legs and wings producing a shortened distance between these appendages (LWD). In this paper the genetic basis of susceptibility to OHP is explored and compared to the control of susceptibility to glucosamine (GA) which also produces a crc phenocopy. The data suggest that genes providing resistance to the effects of GA are different from those conferring resistance to OHP. Furthermore, genes providing resistance to the crc effects of OHP appear to be different from those controlling resistance-to the LWD effects. Intrastrain gene coadaptation also seems to be important in resistance to OHP. The relevance of these results to the problem of the genetic control of developmental buffering is briefly discussed.

References

May 1, 1975·The Journal of Experimental Zoology·E W Rapport
Jul 1, 1973·The Journal of Experimental Zoology·E W Rapport
Sep 15, 1974·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·E W Rapport, M K Yang
Aug 16, 1952·Nature·F W ROBERTSON, E C R REEVE
Jan 1, 1961·Advances in Genetics·C H WADDINGTON

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Citations

May 18, 2013·Developmental and Comparative Immunology·Jie Xu, Sara Cherry
Mar 29, 1991·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A Lumsden

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