Genetic control of susceptibility to mycobacterial infections

Reviews of Infectious Diseases
E Skamene

Abstract

Susceptibility of mice to the establishment of infection after exposure to mycobacteria is controlled by a single, dominant, autosomal gene: the Bcg gene. It is located on the centromeric portion of chromosome 1 within a linkage group that shows structural homology with a conserved region of human chromosome 2. The Bcg gene regulates directly the process of T cell-independent macrophage activation for antimycobacterial function and, indirectly, the magnitude and the quality of specific immune response to mycobacterial antigens.

Citations

Apr 28, 1990·Lancet·P E Fine, L C Rodrigues
Feb 7, 2003·Social Science & Medicine·Stacie D A Burke, Lawrence A Sawchuk
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·W D HamiltonR Tanese
Jul 4, 2001·Clinical Microbiology Reviews·N B Harris, R G Barletta
Feb 1, 1995·Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·M BoseK Saha
Apr 1, 1994·Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·R L SepulvedaR U Sorensen
Jul 1, 1995·Journal of Comparative Pathology·R S VeazeyT G Snider
Jul 1, 1991·International Journal of Dermatology·S T NedorostC Camisa
Oct 1, 1993·Immunology and Cell Biology·J F Griffin, G S Buchan
Feb 15, 1990·The New England Journal of Medicine·W W SteadJ P Lofgren
Jan 1, 1993·The American Journal of the Medical Sciences·J C Weissler

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Related Papers

The Journal of Pathology and Bacteriology
I LOMINSKIG B ROBERTS
Social History of Medicine : the Journal of the Society for the Social History of Medicine
W Rutten
Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
V Mizrahi
© 2022 Meta ULC. All rights reserved