Genetic control of T helper cell function in the clawed toad Xenopus laevis

European Journal of Immunology
C C BernardL Du Pasquier

Abstract

The genetic control of the collaboration between Xenopus T and B cells has been analyzed in vivo using cells from five strains of major histocompatibility complex-defined Xenopus. When carrier (fowl gamma-globulin)-primed T cells and hapten (dinitrophenylated keyhole limpet hemocyanin)-primed B cells differed by minor histocompatibility antigens or by only one haplotype of the major histocompatibility complex, the collaboration was efficient in the sense that large numbers of plaques, low-molecular weight antibodies and high-affinity IgM antibodies could be recorded in the cultures challenged with dinitrophenylated fowl gamma-globulin. However, when T and B cells differed at both alleles of the major histocompatibility complex, lower numbers of plaques were obtained, no low-molecular weight anti-hapten antibodies could be detected, and the IgM antibodies that were sometimes synthesized were of low affinity. This suggests that the major histocompatibility complex, or a gene linked with it, affects the collaboration between Xenopus T and B cells in a way perhaps similar to that described in mammals.

References

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Citations

Jan 1, 1985·Developmental and Comparative Immunology·L N RubenM Balls
Jan 1, 1986·Developmental and Comparative Immunology·R H ClothierM Balls
Jan 1, 1989·Developmental and Comparative Immunology·R H ClothierM Balls
Sep 1, 1993·Developmental and Comparative Immunology·F A HardingN Cohen
Jan 1, 1987·Immunology Today·M F FlajnikL D Pasquier
Feb 1, 1996·Immunological Reviews·P McCullagh
May 1, 1992·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·L Du Pasquier
Jan 1, 1985·Differentiation; Research in Biological Diversity·J Schwager, I Hadji-Azimi
Mar 1, 1983·Immunology Today·N Cohen, G W Warr
Feb 1, 1990·Immunological Reviews·M F Flajnik, L Du Pasquier
Nov 1, 1980·European Journal of Immunology·B BlombergL Du Pasquier
Sep 1, 1990·European Journal of Immunology·M A Farag, R el Ridi

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