PMID: 10335Aug 1, 1976

Genetic control of the antibody response to type III pneumococcal polysaccharide in mice. III. Analysis of genes governing the expression of regulatory T cell activity

Journal of Immunogenetics
P J BakerP W Stashak

Abstract

Recombinant-inbred strains of mice, as well as the progenitor strains from which they were derived, were evaluated with respect to the capacity of B cells to respond to an optimally immunogenic dose of Type III pneumococcal polysaccharide (SSS-III) and the amount of suppressor and amplifier T cell activity present. None of these functional activities was found to be linked to genes within the major histocompatibility (H-2) or the IgCH allotype complex, and several autosomal genes appeared to govern the expression of each of these characteristics.

References

Jan 1, 1975·Transplantation Reviews·T TadaT Takemori
Jun 1, 1973·The Journal of Experimental Medicine·P J BakerB Prescott
Feb 1, 1974·Cellular Immunology·H Braley-MullenM J Freeman

Related Concepts

Antibody Formation
B-Lymphocytes
Cistron
SD Antigens
Natural Immunosuppression
Immunoglobulin Allotypes
Genetic Linkage Analysis
Polysaccharides, Bacterial
Recombination, Genetic
Streptococcus pneumoniae

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