Genetic control of the fucosylation of ABH precursor chains. Evidence for new epistatic interactions in different cells and tissues

Journal of Immunogenetics
R Oriol

Abstract

The general structure of the ABH antigens is analysed taking into account six possible precursor chains and two alpha-2-fucosyltransferases. The classical genetic model with one structural gene and two regulatory genes for the synthesis of the H antigen and the events which prompted the proposal of the new model with two structural genes for the synthesis of H determinants are discussed. Three human alpha-3-fucosyltransferases with different acceptor specificity are presented. Myeloid type of alpha-3-fucosyltransferase, which transfers fucose on to H type 2, serum type of alpha-3-fucosyltransferase, which transfers fucose on to H type 2 and sialyl-N-acetyl-lactosamine and Lewis or alpha-3/4-fucosyltransferase, which transfers fucose on to H type 1 and H type 2 and the corresponding sialylated structures. The presence of different ABH and Lewis antigens in different tissues and the different epistatic interactions needed to account for their synthesis are analysed in terms of new epistatic interactions with either the known fucosyltransferases or with new fucosyltransferases.

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Citations

Oct 8, 2013·Journal of the American Society for Mass Spectrometry·Ling HanJohn S Klassen
Aug 3, 2012·Journal of Virology·Tomomi KubotaHaruko Shirato
Aug 15, 2008·Journal of Virology·Haruko ShiratoNaokazu Takeda
Apr 30, 2013·Emerging Infectious Diseases·Melissa M Herbst-KralovetzCheryl A Nickerson
Jun 28, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M TasakiK Takahashi
Nov 26, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M JeyakanthanL J West
Sep 18, 2008·The Journal of Medical Investigation : JMI·Eiji Hosoi
May 28, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M JeyakanthanL J West
Jun 23, 2007·International Journal of Cancer. Journal International Du Cancer·Sylvie MathieuAssou El-Battari
Jan 19, 2016·Archives of Virology·Sangdo HaJinjong Myoung
Apr 21, 2021·The Journal of Clinical Investigation·Jane Hc LoongStephanie Ky Ma
Jun 1, 1993·Baillière's Clinical Haematology·J B Lowe
Aug 31, 2010·Biochemical and Biophysical Research Communications·Nicholas PettitPeng George Wang

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