PMID: 109505Mar 1, 1979

Genetic control of the immune response to staphylococcal nuclease. IX. Recombination between genes determining BALB/c antinuclease idiotypes and the heavy chain allotype locus

The Journal of Immunology : Official Journal of the American Association of Immunologists
D S PisetskyD H Sachs

Abstract

The genetic linkage relationship of two antinuclease idiotypes produced by the BALB/c strain was investigated in the backcross (BALB/c x CB.20) X CB.20. These two idiotypes were detected by Lewis rat anti-idiotypic antisera prepared against affinity-purified A/J and SJL antinuclease antibodies, termed the A/J and SJL idiotypes, respectively. Both idiotypes were found to be linked to the IgCHa immunoglobulin heavy chain allotype locus. There was, however, a high frequency of recombination observed between both markers and the IgCHa locus, with eight of 83 backcross animals recombinant for the A/J idiotype and five of 83 recombinant for the SJL idiotype. All such recombinant animals were IgCHb/b homozygotes that had gained one or both idiotypes. These results are consistent with a genetic map of VHr region genes in the BALB/c strain in which genes determining the SJL idiotype are closer to the IgCHa allotype locus than are genes determining the A/J idiotype. This high frequency of recombination may indicate that the chromosome segment containing VH region genes is very large or that it has structural features that promote recombination.

Related Concepts

Antibody Formation
Genome Mapping
Crosses, Genetic
Immunoglobulin Allotypes
Immunoglobulin Idiotypes
Immunoglobulin Heavy Chain Subgroup VH-III
Mice, Inbred A
Mice, Inbred BALB C
Micrococcal Nuclease
Rats, Inbred Lew

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