Genetic controls and cellular behaviors in branching morphogenesis of the renal collecting system.

Wiley Interdisciplinary Reviews. Developmental Biology
Frank Costantini


The mammalian kidney, which at maturity contains thousands of nephrons joined to a highly branched collecting duct (CD) system, is an important model system for studying the development of a complex organ. Furthermore, congenital anomalies of the kidney and urinary tract, often resulting from defects in ureteric bud branching morphogenesis, are relatively common human birth defects. Kidney development is initiated by interactions between the nephric duct and the metanephric mesenchyme, leading to the outgrowth and repeated branching of the ureteric bud epithelium, which gives rise to the entire renal CD system. Meanwhile, signals from the ureteric bud induce the mesenchyme cells to form the nephron epithelia. This review focuses on development of the CD system, with emphasis on the mouse as an experimental system. The major topics covered include the origin and development of the nephric duct, formation of the ureteric bud, branching morphogenesis of the ureteric bud, and elongation of the CDs. The signals, receptors, transcription factors, and other regulatory molecules implicated in these processes are discussed. In addition, our current knowledge of cellular behaviors that are controlled by these genes and underlie developme...Continue Reading


Jul 1, 1987·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·L Saxén, H Sariola
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·Q C VegaG R Dressler
Jan 24, 1998·Developmental Biology·C V PepicelliA P McMahon
Dec 16, 1998·Kidney International·Q al-Awqati, M R Goldberg
Jan 19, 1999·Current Topics in Developmental Biology·T CarrollP D Vize
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·J QiaoS K Nigam
Mar 8, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A Raatikainen-AhokasH Sariola
Apr 5, 2000·The Journal of Clinical Investigation·Y MiyazakiI Ichikawa
Sep 7, 2001·Cytokine & Growth Factor Reviews·M Takahashi
Feb 16, 2002·Developmental Biology·Ming-Jer TangGregory R Dressler
Jun 7, 2002·Genes & Development·Deneen M WellikMario R Capecchi
Nov 19, 2002·Genes & Development·Maxime BouchardMeinrad Busslinger
Jan 1, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Julie DrawbridgeMary E Kite
May 6, 2003·Developmental Biology·Aurora F Esquela, Se-Jin Lee
Sep 4, 2003·Journal of Cell Science·Hannu Sariola, Mart Saarma
Apr 6, 2004·Journal of Anatomy·Lydia Michael, Jamie A Davies
Jun 16, 2004·Developmental Biology·Tomoko Watanabe, Frank Costantini
Sep 18, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Cristina CebriánDoris A Herzlinger
Nov 24, 2004·Differentiation; Research in Biological Diversity·Maxime Bouchard
Dec 8, 2004·Developmental Biology·Haotian ZhaoCarlton M Bates
Dec 29, 2004·Developmental Cell·Reena ShakyaFrank Costantini
Jan 8, 2005·Nephron. Experimental Nephrology·Luise A Cullen-McEwenJohn F Bertram
Feb 5, 2005·Developmental Cell·M Albert BassonJonathan D Licht
May 11, 2005·Cell·Hui ZongLiqun Luo
May 14, 2005·Developmental Biology·Reena ShakyaFrank Costantini
May 27, 2005·Journal of the American Society of Nephrology : JASN·Kai M Schmidt-OttJonathan Barasch
Jul 16, 2005·Developmental Biology·Gangadharan SajithlalPin-Xian Xu
Dec 13, 2005·Nature Genetics·Evelyne FischerMarco Pontoglio
Jan 26, 2006·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Frank Costantini, Reena Shakya
Feb 3, 2006·Genes & Development·Sanjay JainJeffrey Milbrandt

❮ Previous
Next ❯


May 17, 2013·Expert Opinion on Pharmacotherapy·Vincenzo MarottaAntongiulio Faggiano
Jan 24, 2016·Journal of Theoretical Biology·Brodie A J Lawson, Mark B Flegg
Jan 7, 2016·Frontiers in Cell and Developmental Biology·Felix J BoivinDarren Bridgewater
Oct 9, 2014·Journal of Anatomy·Nils O LindströmJamie A Davies
Jan 28, 2016·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Kevin Leclerc, Frank Costantini
Jan 22, 2015·Nephrology·Georgina Caruana, John F Bertram
Jun 28, 2015·Developmental Biology·Elanor N WainwrightPeter Koopman
Jan 23, 2015·Tissue Barriers·Halim KhairallahIndra R Gupta
Nov 5, 2013·Developmental Cell·Adam PackardFrank Costantini
Aug 1, 2014·Seminars in Cell & Developmental Biology·Joshua Blake, Norman D Rosenblum
Aug 5, 2014·Seminars in Cell & Developmental Biology·Tobias Bohnenpoll, Andreas Kispert
Sep 10, 2014·Seminars in Cell & Developmental Biology·Lori L O'Brien, Andrew P McMahon
Jun 28, 2016·Kidney International·Christiane PeuckertKlas Kullander
Aug 3, 2016·Nature Communications·Antoine ReginensiHelen McNeill
Aug 31, 2016·Nature Reviews. Nephrology·Melissa H LittleMinoru Takasato
Nov 4, 2016·Journal of the American Society of Nephrology : JASN·Melissa Helen Little, Pamela Kairath
Feb 7, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Marie-Lyne FillionIndra R Gupta
Nov 4, 2015·Cells·Elisa Agnese NigroAlessandra Boletta
Jan 25, 2018·American Journal of Physiology. Renal Physiology·Michael B Butterworth
Oct 25, 2013·Nature Communications·Maddalena CastelliAlessandra Boletta
Mar 20, 2015·Journal of the American Society of Nephrology : JASN·Annekatrin AueKai M Schmidt-Ott
Aug 26, 2018·Journal of the American Society of Nephrology : JASN·Amelie T van der VenFriedhelm Hildebrandt
Aug 26, 2014·Journal of the American Society of Nephrology : JASN·Brittany L RocqueElena Torban
Oct 29, 2017·Journal of the American Society of Nephrology : JASN·Amelie T van der VenFriedhelm Hildebrandt
Jun 13, 2014·American Journal of Physiology. Renal Physiology·Christopher RymerSunder Sims-Lucas
Jan 11, 2018·The Journal of Biological Chemistry·Kathleen E TumeltyStephen P Berasi
Feb 6, 2020·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Elisabeth A Rutledge, Andrew P McMahon
Mar 13, 2020·Stem Cells Translational Medicine·Biao HuangZhongwei Li
Apr 12, 2020·Journal of Perinatology : Official Journal of the California Perinatal Association·Matthew W HarerKimberly J Reidy
Sep 26, 2020·Physiological Reports·Jasmine El AndalousiIndra R Gupta
Nov 26, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Raphael KopanZhenyi Liu
Jul 24, 2018·Biomicrofluidics·Hiroshi KimuraNorimoto Yanagawa
Dec 22, 2019·Journal of the American Society of Nephrology : JASN·Shoichiro KandaMotoshi Hattori
Nov 13, 2014·Médecine sciences : M/S·Mélanie Paces-Fessy
Nov 30, 2018·Frontiers in Physiology·Kristen KurtzebornSatu Kuure
Mar 30, 2019·Scientific Reports·Hao LiJaan-Olle Andressoo
May 5, 2017·JCI Insight·Samir S El-DahrZubaida Saifudeen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.