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Genetic convergence in the adaptation of dogs and humans to the high-altitude environment of the tibetan plateau

Genome Biology and Evolution

Aug 6, 2014

Guo-Dong WangYa-ping Zhang

Abstract

The high-altitude hypoxic environment represents one of the most extreme challenges for mammals. Previous studies of humans on the Tibetan plateau and in the Andes Mountains have identified statistical signatures of selection in different sets of loci. Here, we first measured the hemogl...read more

Mentioned in this Paper

Epas1 protein, mouse
Genome
Genetic Analysis
Acclimatization
Genetic Screening Method
Candidate Disease Gene
Genetics, Population
Eryhem
Altitude
EPAS1 gene
36
1
2
105
1
Paper Details
References
  • References36
  • Citations25
1234
  • References36
  • Citations25
123

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Genetic convergence in the adaptation of dogs and humans to the high-altitude environment of the tibetan plateau

Genome Biology and Evolution

Aug 6, 2014

Guo-Dong WangYa-ping Zhang

PMID: 25091388

DOI: 10.1093/gbe/evu162

Abstract

The high-altitude hypoxic environment represents one of the most extreme challenges for mammals. Previous studies of humans on the Tibetan plateau and in the Andes Mountains have identified statistical signatures of selection in different sets of loci. Here, we first measured the hemogl...read more

Mentioned in this Paper

Epas1 protein, mouse
Genome
Genetic Analysis
Acclimatization
Genetic Screening Method
Candidate Disease Gene
Genetics, Population
Eryhem
Altitude
EPAS1 gene
36
1
2
105
1

Similar Papers Found In These Feeds

Gene Evolution & Mutation

The identification of precise mutations is required for a complete understanding of the underlying molecular and evolutionary mechanisms driving adaptive phenotypic chang

Hypoxia

Hypoxia is a condition in which the body or a region of the body is deprived of adequate oxygen supply at the tissue level. Hypoxia may be classified as either generalized, affecting the whole body, or local, affecting a region of the body. Here is the latest research.

Related Papers

Genome Biology

Genetic adaptation to high altitude in the Ethiopian highlands

Genome BiologyJanuary 24, 2012
Laura B ScheinfeldtSarah A Tishkoff
Paper Details
References
  • References36
  • Citations25
1234
  • References36
  • Citations25
123
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