Genetic correlation of community-associated methicillin-resistant Staphylococcus aureus strains from carriers and from patients with clinical infection in one region of Korea.

Journal of Korean Medical Science
In-Gyu BaeEun-Yup Lee

Abstract

Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) is an increasingly common worldwide and colonizing S. aureus strains may serve as the causative pathogen for overt clinical infections. This study was performed to determine whether the pathogenic CA-MRSA isolate in clinical infections was genetically related to the MRSA isolates in community carriers. We prospectively collected a total of 42 CA-MRSA isolates (23 clinical infection isolates and 19 colonization isolates) in a local region of Korea. Antimicrobial susceptibility tests, staphylococcal toxin assays, SCCmec typing, multilocus sequence typing (MLST), and spa (staphylococcal protein A) typing were performed with all isolates. Thirty-four (81%) of 42 CA-MRSA isolates belonged to sequence type (ST) 72 in the MLST analysis. The distribution of STs did not differ significantly between colonization and clinical infection isolates (89.5% [17/19] vs. 73.9% [17/23], P=0.26). Among the ST72-MRSA isolates, spa type t664 (18, 52.9%) and t324 (8, 23.5%) were common in both groups. This study demonstrates that the community-associated MRSA strains from patients with clinical infections are closely related to the strains found in carriers from one local community.

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Citations

Jul 27, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A-C UhlemannF D Lowy
Jul 6, 2013·The Lancet Infectious Diseases·Yu-Yu Chuang, Yhu-Chering Huang
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Jun 4, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C-J Chen, Y-C Huang
Mar 15, 2011·Diagnostic Microbiology and Infectious Disease·Jeong-Ok ChaGyung Tae Chung
Jun 15, 2011·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Jina LeeHoan Jong Lee
Apr 21, 2016·Polish Journal of Veterinary Sciences·M RuzauskasC Pomba
Jun 4, 2013·Journal of Food Protection·Birgit Lassok, Bernd-Alois Tenhagen
Sep 21, 2016·Expert Review of Anti-infective Therapy·Kyungmin Huh, Doo Ryeon Chung
Jan 12, 2011·Journal of Food Protection·Chae Hong Rhee, Gun-Jo Woo

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Methods Mentioned

BETA
electrophoresis
PCR

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