Genetic counseling program in familial breast cancer: analysis of its effectiveness, cost and cost-effectiveness ratio

International Journal of Cancer. Journal International Du Cancer
Judith BalmañaM Carmen Alonso

Abstract

Women with a family history of breast cancer are at increased risk for developing this neoplasm. Starting surveillance more frequently at a younger age than the general population and the possibility of undergoing genetic testing are options for their medical management. We analyzed the benefits and costs of our clinical program in familial breast cancer (FBC) and carried out a cost-effectiveness analysis of such procedure. The benefits and costs of performing genetic counseling and a screening program in FBC based on 143 high-risk families registered in our database between June 1995 and December 2001 were analyzed. A decision tree was constructed to estimate the survival benefit and cost-effectiveness of the clinical genetic counseling program compared with the strategy of not performing any screening protocol. We estimated that the prevalence of a BRCA mutation in an unaffected relative of our high-risk cohort was 10% and that 53% of the mutations are found in the BRCA1 gene. We assigned a 58.5% lifetime risk of breast cancer for a 30-year-old mutation carrier according to the SEER data. The effectiveness of the screening was obtained from our experience and data for estimating survival were derived from other studies with l...Continue Reading

Citations

May 21, 2011·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Fernando AntoñanzasM Pinillos
Jun 11, 2011·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·José Manuel Rodríguez BarriosMax Brosa Riestra
Sep 21, 2006·International Journal of Technology Assessment in Health Care·Wolf Rogowski
Mar 31, 2007·Genetic Testing·Shannon KieranKyung Hee Lim
Feb 9, 2012·Genetic Testing and Molecular Biomarkers·William SullivanKatherine Payne
Jan 29, 2011·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Sandjar DjalalovJeffrey Hoch
Sep 19, 2012·Public Health Genomics·M S BowenM J Khoury
Jan 23, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marc D SchwartzLesley King
Jun 8, 2017·Scandinavian Journal of Gastroenterology·Olle SjöströmBeatrice Melin
Dec 21, 2019·Annals of Laboratory Medicine·Jieun KimJongha Yoo
Jul 18, 2015·Cardiology in Review·Patricia ArscottSara Cherny
Jun 21, 2018·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Laura Delgado-OrtegaCarlota Moya-Alarcón
Dec 3, 2016·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Elvira D'AndreaPaolo Villari
Feb 2, 2021·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Andreas KoldehoffDirk Müller

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Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.

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