Genetic Counseling Referral Rates in Long-Term Survivors of Triple-Negative Breast Cancer

Journal of the National Comprehensive Cancer Network : JNCCN
Carlos H BarcenasBanu K Arun

Abstract

Background: Inherited BRCA gene mutations (pathogenic variants) cause 10% of breast cancers. BRCA pathogenic variants predispose carriers to triple-negative breast cancer (TNBC); around 30% of patients with TNBC carry BRCA pathogenic variants. The 2018 NCCN Guidelines for Genetic/Familial High-Risk Assessment: Breast and Ovarian recommend genetic counseling referrals for patients with TNBC diagnosed at age ≤60 years. This study sought to describe genetic counseling referral patterns among long-term TNBC survivors at The University of Texas MD Anderson Cancer Center. Methods: This single-institution retrospective analysis of female long-term (disease-free for ≥5 years) TNBC survivors sought to determine the rate of genetic counseling referral among patients diagnosed at age ≤60 years between 1992 and 2008. Patients who underwent treatment and surveillance visits at our institution and were followed until 2017 were included. We collected BRCA pathogenic variant status among tested patients. Descriptive statistical methods and a univariate analysis were used to identify patient characteristics associated with genetic counseling referral. Results: We identified 646 female long-term TNBC survivors with a median age at diagnosis of 4...Continue Reading

Citations

Feb 19, 2020·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Sonya ReidTuya Pal
Jul 5, 2019·The Breast Journal·Anne H BlaesJennifer R Klemp
May 18, 2019·American Society of Clinical Oncology Educational Book·Stephanie A CohenBanu K Arun
Dec 10, 2020·The American Surgeon·Trevor J TeetorBruce A Kerner
Mar 13, 2021·Targeted Oncology·Laura CortesiChristian Jackisch
Apr 7, 2021·Journal of Cancer Education : the Official Journal of the American Association for Cancer Education·Pearman D ParkerJean C McSweeney
Apr 9, 2021·Breast Cancer Research and Treatment·Andrew E JohnsonRachel B Jimenez

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