Genetic deficiency and polymorphisms of cyclophilin A reveal its essential role for Human Coronavirus 229E replication

Current Opinion in Virology
Albrecht von BrunnJavier Carbajo-Lozoya

Abstract

Replication of coronaviruses is inhibited in vitro by cyclosporin A, a well-known immunosuppressive drug which binds to cellular cyclophilins thus inactivating their enzymatic cis-trans peptidyl-prolyl isomerase function. Latter is required for proper folding of cellular proteins and of proteins of several viruses. Here, we summarize present knowledge on the role of cyclophilin A during coronavirus replication. We present data on the effect of cyclophilin A single nucleotide polymorphism mutants on the replication of human CoV-229E demonstrating the requirement of proper cyclophilin A function for virus propagation. Results define cellular cyclophilin A as a host target for inhibition of coronaviruses ranging from relatively mild common cold to highly pathogenic SARS-CoV and MERS-CoV viruses with the perspective of disclosing non-immunosuppressive cyclosporin A analogs to broadly inactivate the coronavirus family.

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Dec 3, 2016·The Journal of General Virology·Yoshikazu TanakaTakashi Sasaki
Jul 14, 2020·Immunological Reviews·Inna G OvsyannikovaRichard B Kennedy
May 16, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jean-Michel Pawlotsky
Aug 11, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Nadia Nicholine PoulsenMartin Blomberg Jensen
May 8, 2020·Antimicrobial Agents and Chemotherapy·Laurent SofticAbdelhakim Ahmed-Belkacem
Feb 20, 2021·ACS Chemical Neuroscience·Kartikay PrasadVijay Kumar
Aug 20, 2020·American Journal of Human Genetics·Marissa LoPrestiBenjamin D Solomon
Jun 1, 2021·The Journal of Biological Chemistry·John P Evans, Shan-Lu Liu
Jun 24, 2021·Journal of Molecular Biology·Jasmina S RedzicElan Zohar Eisenmesser
Oct 19, 2021·Saudi Journal of Biological Sciences·Muhammad Farhat UllahM Y Malik

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Methods Mentioned

BETA
Y2H
surface
biosensor
gene knockout

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