Genetic deficiency of chemokine receptor CCR5 is a strong risk factor for symptomatic West Nile virus infection: a meta-analysis of 4 cohorts in the US epidemic

The Journal of Infectious Diseases
Jean K LimPhilip M Murphy

Abstract

West Nile virus (WNV) causes disease in approximately 20% of infected humans. We previously reported that homozygosity for CCR5Delta32, a nonfunctional variant of chemokine receptor CCR5, is markedly increased among symptomatic WNV-seropositive patients from Arizona and Colorado. To confirm this, we analyzed cohorts from California and Illinois. An increase in CCR5-deficient subjects was found in both (for California, odds ratio [OR], 4.2 [95% confidence interval {CI}, 1.5-11.9] [P= .004]; for Illinois, OR, 3.1 [95% CI, 0.9-11.2] [P= .06]). A meta-analysis of all 4 cohorts showed an OR of 4.2 (95% CI, 2.1-8.3 [P= .0001]). Thus, CCR5 deficiency is a strong and consistent risk factor for symptomatic WNV infection in the United States.

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Citations

May 2, 2012·Immunologic Research·Susana V Bardina, Jean K Lim
Apr 16, 2013·Comparative Immunology, Microbiology and Infectious Diseases·Amaia LarruskainBegoña M Jugo
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Huafang LaiQiang Chen
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Sep 6, 2008·The Journal of Infectious Diseases·Jeffrey M JacobsonWilliam C Olson
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