PMID: 6160453Oct 18, 1980Paper

Genetic deficiency of thyroxin-binding protein in 4 members of a family (author's transl)

La Nouvelle presse médicale
R LevratD V Durand

Abstract

Four members of the same family (2 male and 2 female) with normal thyroid function were found to have decreased total T3 and total T4, elevated response to the T3 test and low free thyroxin index. Such biological changes result from a deficiency in carrier protein and should be distinguished from nearly similar abnormalities observed in low T3 syndrome and hypothyroidism. Whilst gonosomal transmission through the X chromosome of thyroxin-binding protein deficiency seems well established, our findings show that another mechanism, i.e. dominant autosomal heredity, is practically certain.

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