Genetic deletion of Lsamp causes exaggerated behavioral activation in novel environments

Behavioural Brain Research
Elizabeth H CataniaPat Levitt

Abstract

The limbic system-associated membrane protein (LAMP) is a GPI-anchored cell adhesion molecule expressed heavily in limbic and limbic-associated regions of the developing and adult brain. Experimental studies show that LAMP promotes the growth of limbic neurons and guides the projections of limbic fibers. In order to examine the functional consequences of disrupting limbic circuit assembly, we generated a mouse line in which the Lsamp gene encoding LAMP was deleted. Basic neuroanatomical organization and sensory and motor development are normal in Lsamp(-/-) mice. The most profound change in behavior in both male and female Lsamp(-/-) mice is a heightened reactivity to novelty exhibited in several behavioral tests. Lsamp(-/-) mice display hyperactivity in a novel arena and both sexes habituate to the same activity levels as their wild type littermates, but at different rates. In the elevated plus maze, Lsamp(-/-) mice exhibit increased total arm entries, with a bias towards the open arms; they spend more time in the open arms and have a substantial increase in the amount of risk assessment in unprotected areas of the maze. In the y-maze, Lsamp(-/-) mice exhibit characteristic hyperactivity and a decreased level of spontaneous al...Continue Reading

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Citations

Jun 7, 2011·Molecular Oncology·Aygül Dereli-ÖzThanos D Halazonetis
Aug 20, 2009·Genes, Brain, and Behavior·R LamprechtJ E LeDoux
Oct 14, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gustavo A PatinoLori L Isom
Dec 14, 2011·Behavioural Brain Research·Jürgen InnosEero Vasar

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