Genetic Deletion of Socs3 in Smooth Muscle Cells Ameliorates Aortic Dissection in Mice

JACC. Basic to Translational Science
Saki HirakataYoshihiro Fukumoto

Abstract

Aortic dissection (AD) is the acute destruction of aortic wall and is reportedly induced by inflammatory response. Here we investigated the role of smooth muscle Socs3 (a negative regulator of Janus kinases/signal transducer and activator of transcription signaling) in AD pathogenesis using a mouse model generated via β-aminopropionitrile and angiotensin II infusion. Socs3 deletion specifically in smooth muscle cells yielded a chronic inflammatory response of the aortic wall, which was associated with increased fibroblasts, reinforced aortic tensile strength, and less-severe tissue destruction. Although an acute inflammatory response is detrimental in AD, smooth muscle-regulated inflammatory response seemed protective against AD.

Citations

May 14, 2020·International Journal of Molecular Sciences·Makiko Hayashi-HoriYoshihiro Fukumoto
Nov 6, 2020·Journal of cardiology·Hiroki AokiSatoko Ohno-Urabe
Apr 6, 2021·Frontiers in Immunology·Yu GaoMartin E Rottenberg

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Methods Mentioned

BETA
dissection
dissections
SMA
genetic modification

Software Mentioned

DAVID
GraphPad
GraphPad Prism
DAVID ( Database for Annotation , Visualization , and Integrat...
ArrayScan
FlowJo

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