Genetic Depletion of Class I Odorant Receptors Impacts Perception of Carboxylic Acids.

Current Biology : CB
Annika CichyThomas Bozza

Abstract

The mammalian main olfactory pathway detects myriad volatile chemicals using >1,000 odorant receptor (OR) genes, which are organized into two phylogenetically distinct classes (class I and class II). An important question is how these evolutionarily conserved classes contribute to odor perception. Here, we report functional inactivation of a large number of class I ORs in mice via identification and deletion of a local cis-acting enhancer in the class I gene cluster. This manipulation reduced expression of half of the 131 intact class I genes. The resulting class I-depleted mice exhibited a significant reduction in the number of glomeruli responding to carboxylic acids-chemicals associated with microbial action and body odors. These mice also exhibit a change in odor perception marked by a selective loss of behavioral aversion to these compounds. Together, our data demonstrate that class I ORs play a critical role in representing a class of biologically relevant chemosignals.

Citations

Oct 22, 2020·The FEBS Journal·Siddhant KalraGaurav Ahuja
Jan 14, 2021·Scientific Reports·Tetsuo IwataJunji Hirota
Mar 16, 2021·Frontiers in Cellular Neuroscience·Artur Guazzelli Leme SilvaBettina Malnic
May 7, 2021·Current Biology : CB·Diogo ManoelLuis R Saraiva

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