Genetic determinants of basal cell carcinoma risk

Medical and Pediatric Oncology
E H Epstein

Abstract

Basal cell carcinomas are can be induced by ionizing radiation, in particular in patients with the rare autosomal dominant basal cell nevus syndrome (BCNS). These patients also are prone to medulloblastomas, and curative ionizing radiation therapy for the latter is followed soon by the development of sheets of basal cell carcinomas in the overlying skin. Positional cloning of the gene mutant is BCNS patients has identified the hedgehog signaling pathway as crucial to the development of all basal cell carcinomas and presumably to this susceptibility to post-ionizing radiation carcinogenesis. Thus this pathway is a candidate for susceptibility to second, post-therapy cancers in the broader population.

References

Mar 1, 1987·Medicine·R J Gorlin
Oct 30, 1980·Nature·C Nüsslein-Volhard, E Wieschaus
May 1, 1994·Journal of the American Academy of Dermatology·D L Miller, M A Weinstock
Mar 4, 2000·Nature Genetics·M GrachtchoukA A Dlugosz

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Citations

Jun 24, 2006·Journal of Pediatric Hematology/oncology·Kudret CağlarMünevver Büyükpamukçu
Apr 7, 2004·The Journal of Clinical Investigation·Xiuwei TangMohammad Athar
Jan 5, 2011·Chinese Journal of Cancer·Hailan LiuJingwu Xie
Apr 29, 2009·Clinical Oncology : a Journal of the Royal College of Radiologists·J LoncasterE Allan
Feb 1, 2006·Cancer Letters·Sumin ChiJingwu Xie
Jun 9, 2004·Neuroimaging Clinics of North America·Simon EdelsteinT Hans Newton
Jan 7, 2015·Archives of Toxicology·Yanfei JiaJingwu Xie
Jul 25, 2009·Nature Reviews. Cancer·Leon MullendersSimon Bouffler
Jul 8, 2008·Acta Biochimica Et Biophysica Sinica·Jingwu Xie
Sep 29, 2015·Oncotarget·Sandeep C ChaudharyMohammad Athar

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Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

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