Genetic determinants of blood pressure traits are associated with carotid arterial thickening and plaque formation in patients with type 2 diabetes

Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease
Line EngelbrechtsenCIMT Trial Group 10

Abstract

The aim of this study is to explore the contribution of genetically driven cardiometabolic risk factors for development of carotid arterial thickening in patients with type 2 diabetes. In total, 12 genetic risk scores for blood pressure, blood lipids and glycaemic traits were constructed. The genetic risk scores were tested for association with carotid intima-media thickness and plaques in patients with type 2 diabetes ( n = 401) and in non-diabetic individuals ( n = 648) and for association with glucose levels in two population-based cohorts ( n = 1328 and n = 6161). In patients with type 2 diabetes, the genetic risk scores for pulse pressure were positively associated with plaque formation ( β = 0.036 ± 0.01 standard deviation/allele, p = 0.003). The genetic risk score for diastolic blood pressure was negatively associated with carotid intima-media thickness ( β = -0.037 ± 0.01 standard deviation/allele, p = 0.005), although not significant after correction for multiple testing ( p < 0.0042). In a meta-analysis of individuals with and without type 2 diabetes, the high-density lipoprotein genetic risk scores showed a trend towards an inverse association with carotid intima-media thickness and plaques, while the low-density lip...Continue Reading

References

Dec 1, 1992·Stroke; a Journal of Cerebral Circulation·P PratiP J Touboul
May 1, 1996·Stroke; a Journal of Cerebral Circulation·R DuggiralaJ Blangero
May 20, 1999·Diabetes Care·T S Temelkova-KurktschievM Hanefeld
May 15, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Anny H XiangHoward N Hodis
Jul 10, 2002·Stroke; a Journal of Cerebral Circulation·Leslie A LangeBarry I Freedman
Apr 16, 2003·Circulation·Ronald M A HenryUNKNOWN Hoorn Study
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·M P M de MaatJ Jespersen
Jun 22, 2007·Clinical and Experimental Pharmacology & Physiology·Carmel M McEnieryAlbert P Avolio
Jul 12, 2008·Stroke; a Journal of Cerebral Circulation·Patrizio PratiPierre-Jean Touboul
Mar 10, 2009·Diabetes, Obesity & Metabolism·L Lundby ChristensenUNKNOWN CIMT Trial Group
Aug 24, 2010·Cardiovascular Diabetology·Louise Lundby-ChristensenNiels Wiinberg
Mar 31, 2011·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Latika SibalPhilip D Home
Feb 1, 2012·Journal of Cardiovascular Translational Research·Jessica E Wagenseil, Robert P Mecham
Oct 8, 2013·Nature Genetics·Cristen J WillerUNKNOWN Global Lipids Genetics Consortium
Jan 6, 2015·Atherosclerosis·Stuart B Prenner, Julio A Chirinos
Jul 14, 2016·American Journal of Hypertension·Benjamin Gavish, Joseph L Izzo
Aug 30, 2016·Nature Genetics·Sayantan DasChristian Fuchsberger

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Methods Mentioned

BETA
Genotyping

Clinical Trials Mentioned

NCT00657943
NCT00289237

Software Mentioned

GenomeStudio
metagen
R
- meta

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