PMID: 108209Apr 1, 1979

Genetic determination of the immune response in mice to cells of different histological type

V A LavrovskyV A Razvorotnev


The intensity of the cellular immune response to strong transplantation antigens of the H-2 complex is related to the histological type of cells taken for immunization. Splenic cells from C3H mice immunized BALB/c mice better than cells of non-lymphoid origin from the same donor. The reverse was observed when, instead of BALB/c mice, C57B1/6 and A/He were used in immunization experiments. Analysis of the inheritance of this immunization pattern studied in mice of the first generation from various crosses between strains (BALB/c, C57B1/6 and A/He) and in mice from backcrosses has demonstrated that this immunization pattern is not inherited as a simple Mendelian character. Therefore, it could be supposed that efficiency of immunological control of cells having different histological types, may be genetically determined.

Related Concepts

Crosses, Genetic
Immunologic Tumoricidal Activities
Ir Genes
Immune Sera
Cellular Immune Response
Lymphoid Cells
Mammary Neoplasms, Experimental
Mice, Inbred Strains
Neoplasm Transplantation
Transplantation, Homologous

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