PMID: 6769180Jan 1, 1980Paper

Genetic differences between C57BL/6 and DBA/2 mice in the inductions of UDP-glucuronyl transferases for 3-hydroxybenzo(a)pyrene, p-nitrophenol, and bilirubin by 3-methylcholanthrene

Toxicology Letters
N Nemoto, S Takayama

Abstract

In C57BL/6 mice, aryl hydrocarbon hydroxylase (AHH) increased 1 day after treatment with 3-methylcholanthrene, and induction of UDP-glucuronyl transferases for 3-hydroxybenzo(a)pyrene, p-nitrophenol and bilirubin in the liver microsomes was observed 2 to 5 days later. In DBA/2 mice, neither AHH nor transferase activities were influenced by 3-methylcholanthrene. These results suggest that induction of activating and detoxicating enzymes is genetically linked.

References

Jul 1, 1978·Chemico-biological Interactions·N NemotoS Takayama
Nov 15, 1969·International Journal of Cancer. Journal International Du Cancer·M DuncanA Dipple
Apr 1, 1967·Biochemical Pharmacology·P Sims

Related Concepts

Metazoa
Xenobiotic Monooxygenases
Benzpyrene
Bilirubin, (4E,15E)-Isomer
Enzyme Induction
Metabolic Detoxication, Drug
Methylcholanthrene
Mice, Inbred C57BL
Mice, Inbred DBA
Mice, Inbred Strains

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