Abstract
Clusters of autoimmune diseases (ADs) are present in some people with type 1 diabetes. This clustering suggests the existence of common genetic backgrounds for abnormal autoimmunity in these individuals. However, the genetic differences between type 1 diabetes patients with and without other ADs are not well known. To investigate the clinical background and genetic differences between type 1 diabetes patients with and without other ADs, single nucleotide polymorphisms (SNPs) in the CTLA4, SUMO4, PTPN22, IRF5, STAT4, and BLK genes were analysed by using either a TaqMan assay or direct sequencing. The frequencies of alleles, genotypes of each gene, and the human leukocyte antigen (HLA) haplotype were analysed to investigate differences among 3 groups: type 1 diabetes with systemic ADs (group A), type 1 diabetes with other organ-specific ADs (group B), and type 1 diabetes without other ADs (group C). The frequency of the C allele in the -1123G > C SNP in the PTPN22 gene promoter was significantly higher in groups A and B than in group C (P = .0258 and .0207, respectively). The allele frequencies of the other SNPs were comparable. The frequency of HLA DRB1*0405-DQB1*0401 was significantly higher in groups A and B than in group C (P...Continue Reading
References
Mar 1, 1990·Diabetes Research and Clinical Practice·G MimuraH Kuzuya
Mar 1, 1988·Arthritis and Rheumatism·F C ArnettH S Luthra
Oct 27, 1997·Arthritis and Rheumatism·M C Hochberg
Dec 2, 1999·Journal of Hepatology·F AlvarezM Zeniya
Mar 25, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E J Heathcote
Feb 24, 2001·Genes and Immunity·O P KristiansenF Pociot
Mar 9, 2004·Nature Genetics·Nunzio BottiniTomas Mustelin
Jul 13, 2004·Nature Genetics·Dehuang GuoCong-Yi Wang
Nov 9, 2004·The Journal of Clinical Endocrinology and Metabolism·M R VelagaS H S Pearce
Nov 8, 2005·Nature Genetics·Torkel VangNunzio Bottini
Dec 15, 2005·The Journal of Clinical Endocrinology and Metabolism·Hiroshi IkegamiToshio Ogihara
Feb 14, 2006·American Journal of Medical Genetics. Part a·Eiji KawasakiKatsumi Eguchi
Jun 1, 2006·The Journal of Clinical Endocrinology and Metabolism·Masako TsurumaruKatsumi Eguchi
Jun 9, 2006·Rheumatology·Y H LeeJ B Harley
Sep 7, 2007·The New England Journal of Medicine·Elaine F RemmersPeter K Gregersen
Jan 22, 2008·The New England Journal of Medicine·Geoffrey HomTimothy W Behrens
Mar 4, 2008·Arthritis and Rheumatism·Aya KawasakiNaoyuki Tsuchiya
Jun 26, 2008·Arthritis and Rheumatism·Shu KobayashiShigeki Momohara
Sep 23, 2008·Arthritis Research & Therapy·Aya KawasakiNaoyuki Tsuchiya
Jan 31, 2009·Arthritis and Rheumatism·Ikue ItoNaoyuki Tsuchiya
May 30, 2009·Arthritis and Rheumatism·Ikue ItoNaoyuki Tsuchiya
Jul 8, 2009·Diabetes Research and Clinical Practice·Masahito KatahiraSatoko Segawa
Jul 17, 2009·Annals of the Rheumatic Diseases·N TsuchiyaS Sato
Sep 11, 2009·Annals of the Rheumatic Diseases·Ikue ItoNaoyuki Tsuchiya
Feb 5, 2010·Arthritis and Rheumatism·Ikue ItoNaoyuki Tsuchiya
Jan 5, 2011·Rheumatology International·Jian-Jun HuangChun-Li Yang
Jul 12, 2011·Diabetes/metabolism Research and Reviews·Ana M WägnerUNKNOWN T1DGC6
Oct 1, 2011·Cell Biochemistry and Biophysics·Fang LiuYu-wu Zhao
Dec 17, 2011·Autoimmunity Reviews·Tai-Ping Lee, Bor-Luen Chiang
May 21, 2014·Journal of Diabetes Investigation·Eiji KawasakiToshiaki Hanafusa