Genetic differences in ethanol-induced conditioned taste aversion after ethanol preexposure

Alcohol
F O Risinger, C L Cunningham

Abstract

The present studies examined the development of ethanol-induced conditioned taste aversion in C57BL/6J (B6) and DBA/2J (D2) mice with a history of ethanol preexposure. In Experiment 1, adult male B6 and D2 mice received four preexposure injections of either saline or 4 g/kg ethanol over an 8-day period. After preexposure, all mice were given five conditioning trials consisting of 1-h access to 0.15% w/v saccharin solution followed immediately by ethanol injections (4 g/kg, IP) on all but the last trial. Drug-naive D2 mice showed greater reductions in saccharin intake. Ethanol preexposure reduced the development of ethanol-induced taste aversion in each strain. However, B6 mice showed little taste aversion overall, hindering the characterization of genetic differences in ethanol's preexposure effect. To address this problem, the parameters for taste conditioning were changed in Experiment 2 to more closely match degree of taste aversion in drug-naive mice across both strains. B6 and D2 mice received four preexposure injections of either saline, 2 g/kg ethanol, or 4 g/kg ethanol, or 4 g/kg ethanol. Subsequently, mice received five conditioning trials consisting of 1-h access to 0.2 M NaCl flavor followed by 4 g/kg ethanol (B6 mic...Continue Reading

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Citations

May 2, 2003·Hippocampus·Adam Z Weitemier, Andrey E Ryabinin
Jan 1, 1996·Life Sciences·F O Risinger, M M Brown
Dec 13, 2000·Pharmacology, Biochemistry, and Behavior·F O Risinger, C L Cunningham
Aug 15, 2002·Pharmacology, Biochemistry, and Behavior·Ivana Grakalic, Anthony L Riley
Sep 6, 2002·Pharmacology, Biochemistry, and Behavior·Ivana Grakalic, Anthony L Riley
Feb 24, 2001·Behavioural Pharmacology·C L Cunningham, C M Henderson
Nov 9, 2010·Addiction Biology·Brian A McCool, Ann M Chappell
Oct 1, 2011·Addiction Biology·Tara L FidlerChristopher L Cunningham
Oct 2, 1998·Alcoholism, Clinical and Experimental Research·F O Risinger, C L Cunningham
Jun 11, 1998·Alcoholism, Clinical and Experimental Research·F O RisingerR A Oakes
Aug 12, 1999·Alcoholism, Clinical and Experimental Research·V J WhatleyV G Erwin
Sep 2, 1999·Alcoholism, Clinical and Experimental Research·M J ThrasherF O Risinger
Mar 23, 2007·Genes, Brain, and Behavior·Y A BlednovR F Margolskee
Jun 4, 2005·The European Journal of Neuroscience·Claire Matson CannonRichard D Palmiter
Feb 28, 2006·Alcoholism, Clinical and Experimental Research·Tara L FidlerChristopher L Cunningham
Sep 24, 2010·Alcoholism, Clinical and Experimental Research·Rachel I AndersonLinda P Spear
Mar 6, 2010·Annals of the New York Academy of Sciences·Catherine M Davis, Anthony L Riley
Mar 17, 2005·Alcoholism, Clinical and Experimental Research·Yann PellouxDominique Duterte-Boucher
Apr 25, 2018·Alcoholism, Clinical and Experimental Research·Christopher A VarnonCharles I Abramson
Dec 20, 2018·Frontiers in Genetics·Diana ZhouLu Lu

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