Genetic differences in hemoglobin function between highland and lowland deer mice.

The Journal of Experimental Biology
Jay F StorzAngela Fago

Abstract

In high-altitude vertebrates, adaptive changes in blood-O(2) affinity may be mediated by modifications of hemoglobin (Hb) structure that affect intrinsic O(2) affinity and/or responsiveness to allosteric effectors that modulate Hb-O(2) affinity. This mode of genotypic specialization is considered typical of mammalian species that are high-altitude natives. Here we investigated genetically based differences in Hb-O(2) affinity between highland and lowland populations of the deer mouse (Peromyscus maniculatus), a generalist species that has the broadest altitudinal distribution of any North American mammal. The results of a combined genetic and proteomic analysis revealed that deer mice harbor a high level of Hb isoform diversity that is attributable to allelic polymorphism at two tandemly duplicated alpha-globin genes and two tandemly duplicated beta-globin genes. This high level of isoHb diversity translates into a correspondingly high level of interindividual variation in Hb functional properties. O(2) equilibrium experiments revealed that the Hbs of highland mice exhibit slightly higher intrinsic O(2) affinities and significantly lower Cl(-) sensitivities relative to the Hbs of lowland mice. The experiments also revealed dist...Continue Reading

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Dec 4, 2013·Proceedings of the National Academy of Sciences of the United States of America·Joana Projecto-GarciaJay F Storz
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