Genetic differences in locomotor activation in mice

Pharmacology, Biochemistry, and Behavior
J C Crabbe

Abstract

Two highly inbred strains of mice were found to differ in habituation of activity repeatedly assessed in a toggle-box exploration task. The recombinant inbred (RI) strains derived from their cross resembled either one or the other parent strain, suggesting that a single gene exerts a marked influence on this behavior. The influence of an acute ethanol injection on activity in an open field was found to differ among 19 inbred strains. In 6 strains significant decreases in activity from the previous day's scores were seen; in two strains activity increased; and in 11 strains, no significant change was seen. Genetic specificity must, therefore, be considered in the interpretation of pharmacologic substrates for activity in mice. Lines of mice selectively bred for high and low open-field activity are suggested to offer an ideal subject population for neuropharmacologic studies.

References

Mar 1, 1991·Alcoholism, Clinical and Experimental Research·B C DudekM E Hahn
Aug 1, 1970·Behavior Genetics·J C DeFriesG E McClearn
Mar 1, 1982·Behavioural Brain Research·J C CrabbeS Kerbusch
Jan 1, 1983·Pharmacology, Biochemistry, and Behavior·K Kiianmaa, B Tabakoff
Jun 1, 1982·Journal of Comparative and Physiological Psychology·J C CrabbeE R Young
Nov 1, 1982·Pharmacology, Biochemistry, and Behavior·B Tabakoff, K Kiianmaa
Dec 1, 1980·Pharmacology, Biochemistry, and Behavior·J Masur, R Boerngen

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Citations

Jul 1, 1990·Physiology & Behavior·A J Parker, K A Clarke
Sep 1, 1992·Physiology & Behavior·J M NeiderhiserG E McClearn
Jul 1, 1987·Pharmacology, Biochemistry, and Behavior·J C CrabbeA Kosobud
Nov 19, 2003·European Journal of Pharmacology·Frauke Ohl, Martin E Keck
Nov 20, 2003·Neuroscience and Biobehavioral Reviews·Davide ViggianoAdolfo G Sadile
Feb 7, 2002·Pharmacology, Biochemistry, and Behavior·William J McBride
Mar 25, 1998·Pharmacology, Biochemistry, and Behavior·M N CookB C Jones
Nov 14, 2002·Behavioural Brain Research·Xiangdong TangLarry D Sanford
Dec 20, 1999·Behavioural Brain Research·J FrohlichD Pfaff
Aug 6, 1998·Neuroscience·D R SmithM Gallagher
Dec 26, 2001·Psychoneuroendocrinology·Therese A Kosten, Emilio Ambrosio
Jun 15, 2001·ILAR Journal·R E BrownH M Schellinck
Apr 1, 1995·Alcoholism, Clinical and Experimental Research·T J PhillipsE H Shen
Dec 12, 1997·Alcoholism, Clinical and Experimental Research·B Hitzemann, R Hitzemann
Sep 3, 1998·Alcoholism, Clinical and Experimental Research·N J GrahameC L Cunningham
Nov 5, 1998·Alcoholism, Clinical and Experimental Research·K DemarestR Hitzemann
Feb 24, 1999·Alcoholism, Clinical and Experimental Research·K DemarestR Hitzemann
Jul 14, 2005·Genes, Brain, and Behavior·D KimH-S Shin
Aug 25, 2001·Annual Review of Neuroscience·J M WehnerB J Bowers
Feb 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·X ZhuangR Hen
Jan 22, 2005·Scandinavian Journal of Psychology·Pia K Leppänen, S Béatrice M Ewalds-Kvist
Mar 17, 2005·Alcoholism, Clinical and Experimental Research·Barbara J BowersJeanne M Wehner
Aug 23, 2003·Genes, Brain, and Behavior·C DowningB C Dudek
Oct 29, 2009·Alcoholism, Clinical and Experimental Research·Eric W FishC J Malanga
Jan 12, 2005·Physiology & Behavior·Xiangdong Tang, Larry D Sanford
Dec 24, 2003·Addiction Biology·D M HixJ M Wehner

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