Genetic differences in susceptibility of chicken lines to infection with infectious bursal disease virus

Poultry Science
N BumsteadJ Cook

Abstract

Mortality rates in 11 inbred and partially inbred chicken lines inoculated with a very virulent strain (CS89) of infectious bursal disease virus (IBDV) varied considerably, being highest (almost 80%) in a Brown Leghorn line (BrL). Bursa of Fabricius to body weight ratios were depressed in the survivors in each line, but no differences were observed between lines. However, histological examination of bursae from survivors showed that, although bursal damage occurred in every line, it was most severe in the two lines (BrL and White Leghorn W1) in which the highest mortality was recorded. Experiments with F1 matings between highly susceptible and highly resistant lines showed that resistance was partially dominant and that there were no maternal effects. Experiments using F2 and backcross chicks suggested the involvement of a single gene and indicated no involvement of the MHC. There was considerable variation between lines in IBDV-specific antibody, measured by ELISA, both in the vaccinated parent hens and in the amounts of inherited maternal antibody and its rate of decay in the progeny.

Citations

Mar 1, 2009·Animal : an International Journal of Animal Bioscience·G DaviesE Giuffra
Dec 12, 2003·Proceedings. Biological Sciences·Jennifer L GrindstaffEllen D Ketterson
Oct 29, 2005·Journal of Virology·Dolores GonzálezFernando Abaitua
Oct 25, 2002·Avian Pathology : Journal of the W.V.P.A·Mohamed K HassanMona M Aly
Jun 1, 2000·Avian Pathology : Journal of the W.V.P.A·T P Berg
Sep 9, 2005·Avian Pathology : Journal of the W.V.P.A·Maxwell O OtimMagne Bisgaard
May 17, 2008·Avian Pathology : Journal of the W.V.P.A·O L NielsenP H Jørgensen
May 17, 2008·Avian Pathology : Journal of the W.V.P.A·J O Okoye, E P Aba-Adulugba
Jun 9, 2004·Veterinary Immunology and Immunopathology·Henk K ParmentierDirk Berkvens
Apr 10, 2013·Developmental and Comparative Immunology·Fiona IngraoThierry van den Berg
Mar 18, 2015·PloS One·Wenke RuanYanhua Wu
May 30, 2002·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Darja Barlic-MaganjaJoze Grom
Jan 19, 2017·International Journal of Molecular Sciences·Yao Qin, Shijun J Zheng
Jul 11, 2021·Ecology Letters·Julie GauzereJosephine M Pemberton
Aug 9, 2019·Journal of Agricultural and Food Chemistry·Yousef I HassanMoussa S Diarra

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.