Genetic differences in susceptibility to chemically induced myelotoxicity and leukemia

Environmental Health Perspectives
D W Nebert

Abstract

The Ah locus represents a complex "cluster" of genese controlling the induction of numerous drug-metabolizing enzyme "activities" by polycyclic aromatic compounds. Allelic differences at the Ah locus are reflected in the large differences in inducibility of cytochrome P1-450 and benzo[a]pyrene metabolism in numerous tissues when the mice receive the chemical daily in their diet. This experimental model system offers to the hematologist and clinical pharmacologist a means to study genetic differences in toxic chemical depression of the bone marrow, as well as a potential model to study aplastic anemia and leukemia explainable on a single-gene basis. The genetically "responsive" individual who is at increased risk for cancer caused by subcutaneous or topical or intratracheal polycyclic hydrocarbons is at decreased risk for toxicity of the bone marrow and leukemia caused by oral benzo[a]pyrene (when compared with the genetically "nonresponsive" individual receiving the same dose of the same xenobiotic). In other words, tissue sites in direct contact with the carcinogen develop cancer in responsive animals because of induced P1-450; tissues in distant sites of the body may develop malignancy in nonresponsive animals because more ca...Continue Reading

References

Aug 1, 1976·Biochemical Genetics·M L CoomesD L Busbee
Mar 25, 1978·Lancet·B Cohen
Jan 1, 1975·Cold Spring Harbor Symposia on Quantitative Biology·S K ChattopadhyayW P Rowe
Oct 15, 1978·International Journal of Cancer. Journal International Du Cancer·E WardM B Havens
May 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·J M EssigmannG N Wogan
Apr 1, 1979·Australian and New Zealand Journal of Medicine·W S SelbyN D Gallagher
Jan 1, 1979·Annual Review of Pharmacology and Toxicology·P A Routledge, D G Shand
Mar 15, 1979·International Journal of Cancer. Journal International Du Cancer·C G GahmbergO Mäkelä
Mar 15, 1979·International Journal of Cancer. Journal International Du Cancer·B PaigenP Sartori
Nov 1, 1979·British Journal of Haematology·W Tillmann, W Schröter
Feb 4, 1978·British Medical Journal·M P VesseyP Wiggins
Feb 1, 1978·The Journal of Experimental Medicine·M L Duran-ReynalsK J Blank
Mar 23, 1978·The New England Journal of Medicine·J Lieberman
Nov 1, 1978·Southern Medical Journal·S B Cohen, R F Burk
Aug 18, 1977·The New England Journal of Medicine·B PaigenN T Hayner
Nov 1, 1973·The New England Journal of Medicine·G KellermannM Luyten-Kellerman
May 15, 1974·International Journal of Cancer. Journal International Du Cancer·R E KouriC E Whitmire
Jul 1, 1967·Archives of Environmental Health·I West
Apr 7, 1973·British Medical Journal·B Joorabchi, E Kohout
Sep 1, 1973·American Journal of Obstetrics and Gynecology·F PetterssonS J Nillius
Feb 1, 1973·Physiology & Behavior·A A GerallU C Cooper
Sep 1, 1968·Archives of Environmental Health·G K Tokuhata
Jan 1, 1980·Pharmacology·C LegraverendJ M Holland
Jan 1, 1980·Journal of Cancer Research and Clinical Oncology·H W RüdigerE Hain
Aug 1, 1961·Archives of Environmental Health·E C HAMMOND
Jul 14, 1962·JAMA : the Journal of the American Medical Association·A J ERSLEV, M M WINTROBE

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Citations

Apr 1, 1982·Environmental Health Perspectives·H Shichi, D W Nebert
Feb 1, 1985·Archives of Toxicology·S W BigelowD W Nebert
Nov 1, 1984·Archives of Toxicology·R A LubetR E Kouri
Jun 7, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C D Booker, K L White
Aug 1, 1998·Mutation Research·F P Guengerich, T Shimada
Sep 1, 1988·Archives of Environmental Contamination and Toxicology·H MohammadpourS J Stohs
Jan 1, 1989·Critical Reviews in Toxicology·D W Nebert
Jan 1, 1984·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·A R Boobis, D S Davies
Dec 13, 2000·The Journal of Pediatrics·J A YanovskiN G Sebring
Sep 30, 1983·Toxicology and Applied Pharmacology·C LegraverendD W Nebert
Jan 1, 1985·American Journal of Industrial Medicine·M M Gad-el-KarimM S Legator

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