PMID: 3770119Nov 1, 1986Paper

Genetic differences in the effects of delta-aminolevulinic acid on seizure latency in mice

Experimental Neurology
J M Wehner, R J Marley

Abstract

delta-Aminolevulinic acid, an intermediate in heme formation, is elevated in certain human disorders including acute intermittent porphyria, tyrosinemia, and lead poisoning. It has been implicated in the central nervous system manifestations of these disorders via interactions with the GABAergic system. This potential interaction was examined by testing whether or not delta-aminolevulinic acid could alter the latency to seizure in mice. Seizures were induced in a variety of inbred strains of mice including C57BL, C3H, DBA mice and in a heterogeneous stock of mice. Flurothyl and 3-mercaptopropionic acid were used to induce seizures in the presence and absence of delta-aminolevulinic acid administered either i.p. (0.5 and 1.5 mmol/kg), or i.c.v. (4.5 and 450 nmol). delta-Aminolevulinic acid increased the latency to myoclonic and clonic seizures induced by flurothyl when administered i.p.; i.c.v. injections also delayed clonic seizures induced by flurothyl, and increased the latency to tonic seizures induced by 3-mercaptopropionic acid. The degree to which delta-aminolevulinic acid altered seizure latency in all tests was dependent on strain of mouse tested. These data support the conclusion that delta-aminolevulinic acid can act ...Continue Reading

References

Aug 9, 1979·Nature·M J Brennan, R C Cantrill
Sep 1, 1977·Medicine·D M Becker, S Kramer
Mar 1, 1986·Pharmacology, Biochemistry, and Behavior·R J MarleyJ M Wehner
Nov 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·H L BonkowskyC J Watson
Apr 1, 1984·Experimental Neurology·R SchwarczE D French
May 1, 1982·Seminars in Liver Disease·H L Bonkowsky, W Schady
Jul 1, 1982·Pharmacology, Biochemistry, and Behavior·A SmolenA C Collins
Aug 1, 1981·Pharmacology, Biochemistry, and Behavior·M J MarksA C Collins

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Citations

Apr 2, 2003·Pharmacology, Biochemistry, and Behavior·Yasuhiko HashimotoYutaka Gomita
Jun 19, 2004·Neurotoxicology and Teratology·Rigao DingKunihiko Obata

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