Genetic differentiation among Sardinian villages.

American Journal of Physical Anthropology
P L WorkmanE Bottini

Abstract

The present study reports an analysis of genetic differentiation among 14 Sardinian villages located mainly in the center of the island. Chi-square tests show significant genetic heterogeneity among villages, and analyses by F- and R- statistics indicate an essentially random pattern of differentiation for all alleles. Using the kinship methods of Morton, a matrix, R, with elements rij describing the correlations between the gene frequencies of villages i and j is obtained. Use of Malécot's formula relating the rij to the geographic distances between villages shows a rapid decline of kinship with increasing distance but reveals essentially no relationship for distances over 40 km. Rotation of a two-dimensional reduction of the kinship matrix to maximum congruence with the geographic distances indicates that about 25% of the genetic distances can be accounted for by the geographic location of the villages. Isolation due in part to cultural factors, genetic drift, and special local or regional patterns of villages associations appear to be involved in the pattern of genetic variation.

References

May 1, 1973·American Journal of Physical Anthropology·N E Morton, J M Lalouel
Nov 27, 1973·Journal of Molecular Evolution·R A Elton
Dec 1, 1971·Theoretical Population Biology·N E MortonR Lew
Jan 15, 1966·Nature·R A Fildes, H Harris
Sep 7, 1963·Nature·D A HOPKINSONH HARRIS
Nov 21, 1964·Nature·N SPENCERH HARRIS

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Citations

Sep 1, 1975·American Journal of Physical Anthropology·R PalmarinoE Bottini
Sep 1, 1976·American Journal of Physical Anthropology·P LucarelliE Bottini
Apr 1, 1982·Journal of Biosocial Science·J H Relethford
Apr 30, 1999·Allergy·N BottiniL Fontana
Feb 24, 2006·European Journal of Human Genetics : EJHG·Veronique VitartIgor Rudan
Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·N E Morton
Jul 1, 1990·Annals of Human Biology·G ZeiP Astolfi
Nov 1, 1992·Annals of Human Biology·D F RobertsP Rudan
Sep 2, 2010·The American Journal of the Medical Sciences·Fulvia Gloria-BottiniEgidio Bottini
Jun 27, 2014·American Journal of Human Biology : the Official Journal of the Human Biology Council·Fulvia Gloria-BottiniEgidio Bottini
Sep 1, 1984·American Journal of Physical Anthropology·A C SwedlundJ H Mielke
Mar 1, 1985·American Journal of Physical Anthropology·J H Relethford
Dec 2, 1999·Nature Genetics·A F WrightM Pirastu
Dec 1, 1981·American Journal of Physical Anthropology·W S Pollitzer
Nov 1, 1987·American Journal of Physical Anthropology·P RudanA Sujoldzić
Dec 1, 1979·Genetical Research·W J Tabachnick, J R Powell
Nov 21, 2019·International Journal of Molecular Sciences·Viola GrugniOrnella Semino
Jan 1, 1996·American Journal of Human Biology : the Official Journal of the Human Biology Council·Giorgio PaoliLuca Taglioli
Aug 1, 1996·American Journal of Physical Anthropology·G VonaP Moral

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